A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan.

MSphere
Junaid IqbalFarah N Qamar

Abstract

Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia.IMPORTANCE The emergence of XDR Salmonella Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one S. Typhi isolate. This finding is important because any possible spread of azithromycin resistance in S. Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan.

References

May 1, 1996·Journal of Medical Microbiology·S H MirzaC A Hart
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Oct 23, 2013·Antimicrobial Agents and Chemotherapy·Sushim Kumar GuptaJean-Marc Rolain
Apr 30, 2014·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliHenrik Hasman
Nov 22, 2014·Nucleic Acids Research·Nicholas J CroucherSimon R Harris
Nov 26, 2014·Genome Medicine·Michael InouyeKathryn E Holt
Oct 6, 2016·Nature Communications·Vanessa K WongUNKNOWN International Typhoid Consortium
Mar 30, 2017·Microbial Genomics·Silvia ArgimónDavid M Aanensen
Mar 22, 2018·MBio·Myron M Levine, Raphael Simon
Feb 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A Crump
Feb 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sushant Sahastrabuddhe, Tarun Saluja
Feb 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mohammad Tahir YousafzaiRumina Hasan
Feb 23, 2019·The Lancet Infectious Diseases·UNKNOWN GBD 2017 Typhoid and Paratyphoid Collaborators
Oct 31, 2019·The Journal of Antimicrobial Chemotherapy·Carl D BrittoAndrew J Pollard

❮ Previous
Next ❯

Citations

Jan 31, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Megan E CareyNeelam Taneja
Jan 27, 2021·Emerging Infectious Diseases·Sophie OctaviaJeanette W P Teo

❮ Previous
Next ❯

Software Mentioned

R
Etest
RedDog
ggtree
ARGannot
RAxML
PlasmidFinder

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved