A rADAR defense against RNAi

Genes & Development
Amy E Pasquinelli

Abstract

Adenosine deaminases that act on RNA (ADARs) convert adenosines (A) to inosines (I) in stretches of dsRNA. The biological purpose of these editing events for the vast majority of ADAR substrates is largely unknown. In this issue of Genes & Development, Reich and colleagues (pp. 271-282) demonstrate that in Caenorhabditis elegans, A-to-I editing in double-stranded regions of protein-coding transcripts protects these RNAs from targeting by the RNAi pathway. Disruption of this safeguard through loss of ADAR activity coupled with enhanced RNAi results in developmental abnormalities and profound changes in gene expression that suggest aberrant induction of an antiviral response. Thus, editing of cellular dsRNA by ADAR helps prevent host RNA silencing and inadvertent antiviral activity.

References

Nov 7, 2002·Molecular Cell·Scott W Knight, Brenda L Bass
Dec 6, 2003·Science·Leath A Tonkin, Brenda L Bass
Sep 13, 2011·Nature Structural & Molecular Biology·Diane WuAndrew Z Fire
May 13, 2014·WormBook : the Online Review of C. Elegans Biology·Allison C BilliJohn K Kim
Nov 28, 2015·Wiley Interdisciplinary Reviews. RNA·Sarah N Deffit, Heather A Hundley
Dec 10, 2015·Nature Reviews. Molecular Cell Biology·Kazuko Nishikura
Dec 30, 2016·Genome Research·Boaz GoldsteinAyelet T Lamm
Mar 28, 2017·RNA Biology·Prajakta BajadMary O'Connell
Feb 28, 2018·Genes & Development·Daniel P ReichBrenda L Bass

❮ Previous
Next ❯

Citations

Jul 8, 2020·Genetics·Joshua A ArribereHeather A Hundley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Current Topics in Microbiology and Immunology
Carl R WalkleyJochen C Hartner
Molecular Cell
Scott W Knight, Brenda L Bass
© 2022 Meta ULC. All rights reserved