A radioimmunoassay for the measurement of pyroglutamyl-histidyl-proline, a proposed thyrotropin releasing hormone metabolite

The Journal of Clinical Endocrinology and Metabolism
T J VisserG Hennemann


A highly specific radioimmunoassay for the measurement of pGlu-His-Pro-OH (TRH-OH), a compound proposed to be a metabolite of pGlu-His-Pro-NH2 (TRH) has been developed. Using this assay experiments have been performed to study the inactivation of TRH and TRH-OH by serum. The results show that TRH-OH is inactivated in a fashion resembling the inactivation of TRH as has been described by others. Support for the deamidation mechanism as the main pathway for TRH degradation could not be achieved.


Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·J T NearyM Soodak
Apr 1, 1980·Molecular and Cellular Endocrinology·E C GriffithsT J Visser
Aug 1, 1982·General and Comparative Endocrinology·E C GriffithsA I Smith

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