PMID: 1482791Sep 1, 1992Paper

A radiotelemetry system for chronic measurement of blood pressure and heart rate in the unrestrained rat validation of the method

Journal of Pharmacological and Toxicological Methods
C GuiolJ M Surgé


Chronic measurements of systemic arterial blood pressure and heart rate via a chronically implanted telemetric transmitter in unrestrained rats, was validated in a three-phase study. In the first part, week-to-week variability of systolic, diastolic, and mean arterial pressures, and heart rate was found to be minimal over the course of nine weeks. In the second part, the reproducibility of cardiovascular response to three successive administration of sotalol, an antihypertensive agent, was studied. In the last part, cardiovascular parameters determined by telemetry were compared to those obtained by direct arterial catheterization and showed a good linear correlation between those two methods.


Feb 1, 1979·Toxicology and Applied Pharmacology·C R HasslerK D Cummings
Apr 15, 1966·Science·R L Van CittersD L Franklin

❮ Previous
Next ❯


Feb 1, 1995·Physiology & Behavior·P K Pilz, C Oedekoven
Aug 1, 1994·Journal of Pharmacological and Toxicological Methods·K SatoS Sato
Mar 30, 1999·European Journal of Pharmacology·R ChanJ White
Sep 6, 2002·Physiology & Behavior·Andrew HarkinJohn P Kelly
Apr 2, 1998·Journal of Pharmacological and Toxicological Methods·R J IrvineR Chan
Apr 1, 1999·Journal of Pharmacological and Toxicological Methods·A M DeveneyD M Jackson
Apr 1, 1999·Journal of Pharmacological and Toxicological Methods·S BalakrishnanJ R McNeill
Mar 15, 1997·Annals of the New York Academy of Sciences·C B Matthew
Jan 24, 1998·Clinical and Experimental Hypertension : CHE·R H BeckerK J Schulze
Jul 1, 1996·Clinical and Experimental Hypertension : CHE·K SatoS Sato
Sep 17, 2010·Bioorganic & Medicinal Chemistry Letters·Olivier CorminboeufAlexander Treiber
Sep 17, 2010·Bioorganic & Medicinal Chemistry Letters·Olivier CorminboeufAlexander Treiber
Jun 21, 2016·Bioorganic & Medicinal Chemistry Letters·Christoph BossJohn Gatfield
Nov 26, 2013·Journal of Medicinal Chemistry·Martin H BolliThomas Weller
Oct 27, 2009·Bioorganic & Medicinal Chemistry Letters·L'ubos RemenWalter Fischli
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T D WilliamsJ M Overton
Jan 20, 2021·Neurotoxicology and Teratology·Timothy J FlaniganSherry A Ferguson
Apr 11, 2009·Journal of Medicinal Chemistry·Olivier BezençonWalter Fischli
Sep 1, 1994·Japanese Journal of Pharmacology·T KatoM Sakanashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.