A random flight chain model for the tether of the Shaker K+ channel inactivation domain

Biophysical Journal
L C Timpe, L Peller

Abstract

Rapid inactivation of Shaker K+ channels occurs when a domain in the amino terminal region of the channel protein blocks the pore. Some part of the sequence between the inactivating domain and the first transmembrane segment may form a flexible tether. We consider the possibility that the tether has no secondary structure, but is rather a polypeptide random coil. The local concentration of the tethered inactivation domain and the dependence of the inactivation rate on chain length can then be calculated by using the Jacobson-Stockmayer equation. A chain of 30-100 amino acids is consistent with the sensitivity of the inactivation rate to chain length mutations.

Citations

Jun 19, 2009·European Biophysics Journal : EBJ·Krzysztof Małysiak, Zbigniew J Grzywna
Jul 31, 2003·Progress in Biophysics and Molecular Biology·Anurag Varshney, M K Mathew
Mar 2, 2016·Nature Structural & Molecular Biology·Lisa D CabritaJohn Christodoulou
Mar 28, 2002·Biophysical Journal·Matthew D LevinDennis Bray
May 13, 2008·Cellular & Molecular Biology Letters·Krzysztof Małysiak, Zbigniew J Grzywna
Jun 19, 2013·Journal of Structural Biology·Xiao-Ping XuNiels Volkmann
Aug 12, 2009·Biochemical and Biophysical Research Communications·Kavitha SankaranarayananM K Mathew
Jul 11, 2006·Biophysical Journal·Bernhard WindischThomas Duke
Oct 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Charlotte S Sørensen, Magnus Kjaergaard
Jun 12, 2017·Cellular and Molecular Life Sciences : CMLS·Magnus Kjaergaard, Birthe B Kragelund
May 8, 2003·European Biophysics Journal : EBJ·Anurag Varshney, M K Mathew

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