Abstract
The efficacy of a single-dose (4 tablets) trimethoprim-sulfamethoxazole (TMP-SMX) was compared with that of a 3-day and 10-day treatment with TMP-SMX, 2 tablets twice daily, in 464 female out-patients with symptoms denoting acute, uncomplicated urinary tract infection (UTI). 321 patients (70%) had significant bacteriuria. Treatment effect could be assessed in 279 women. Comparable results were obtained with the 3 regimens 2 and 6 weeks after treatment. Eradication of the initial organism occurred in 96% with single-dose, in 96-94% with a 3-day, and in 98% with a 10-day course. The incidence of adverse reactions was significantly greater in patients treated with a 10-day (28%) than in those treated with a single-dose (5%), or 3-day (9%) regimen (p less than 0.01). This study suggests that short treatment regimens for uncomplicated UTI in women are as effective as and cause fewer side-effects than the conventional 10-day chemotherapy.
References
Feb 23, 1978·The New England Journal of Medicine·L S FangR H Rubin
Jul 1, 1979·The Journal of Antimicrobial Chemotherapy·J D AndersonR K Percival-Smith
May 5, 1979·British Medical Journal·G Källenius, J Winberg
Jan 17, 1976·British Medical Journal·C A CharltonS Rye
Jan 1, 1977·Nephron·R R Bailey, G D Abbott
Feb 1, 1972·British Journal of Urology·N Slade, S T Crowther
Sep 9, 1967·British Medical Journal·R N Grüneberg, W Brumfitt
Nov 14, 1981·British Medical Journal·R B Harbord, R N Grüneberg
Nov 14, 1981·British Medical Journal·J RapoportF W O'Grady
Jan 1, 1982·Reviews of Infectious Diseases·P Souney, B F Polk
Mar 1, 1982·Reviews of Infectious Diseases·N E Tolkoff-RubinR H Rubin
Mar 1, 1982·Reviews of Infectious Diseases·G W CountsM Turck
Nov 1, 1981·The American Journal of Medicine·C M Kunin
Nov 1, 1981·The American Journal of Medicine·R N GreenbergR L Marier
Citations
Dec 17, 1993·Pharmacy World & Science : PWS·E Van PienbroekJ D Mulder
Sep 28, 2005·World Journal of Urology·F ChristophM Schrader
Jan 1, 1987·Antimicrobial Agents and Chemotherapy·R A Gleckman
Feb 1, 1987·Antimicrobial Agents and Chemotherapy·F GarlandoR Lüthy
Jun 1, 1989·Antimicrobial Agents and Chemotherapy·C I Backhouse, J A Matthews
Aug 1, 1989·Antimicrobial Agents and Chemotherapy·T M HootonW E Stamm
Nov 25, 1989·BMJ : British Medical Journal·T A TrienekensA W Houben
Apr 28, 2004·Journal of General Internal Medicine·Michael B Rothberg, John B Wong
Jan 1, 1992·Infection·H C Neu
Jan 1, 1992·Infection·F Caron, G Humbert
Jun 24, 2010·Expert Opinion on Emerging Drugs·Florian M E WagenlehnerKurt G Naber
Mar 29, 2014·Journal of Veterinary Internal Medicine·S ClareK R Viviano
Mar 7, 2002·Urology·George A RichardJoanna Y Yang
Nov 8, 2005·The American Journal of Medicine·Eugene A KatchmanLeonard Leibovici
Jan 1, 1990·Scandinavian Journal of Infectious Diseases·G ReidM Llano
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Monika Lutters, Nicole B Vogt-Ferrier
Apr 23, 2005·The Cochrane Database of Systematic Reviews·G MiloL Leibovici
Nov 1, 1992·The Journal of International Medical Research·J Guibert, M H Capron
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·A GordinR Antikainen
May 1, 1987·Scandinavian Journal of Primary Health Care·J Sander
Jan 6, 2006·The European Journal of General Practice·Tiny van MerodeEllen Stobberingh