PMID: 11916619Mar 28, 2002Paper

A randomised controlled clinical trial of antibiotic impregnation of testosterone pellet implants to reduce extrusion rate

European Journal of Endocrinology
S KelleherD J Handelsman

Abstract

Testosterone pellet implantation is a safe, effective and convenient form of depot androgen replacement, with extrusion of pellets following about 10% of procedures the most frequent adverse effect. This study aimed to determine whether extrusion rate could be reduced by antibiotic impregnation of pellets immediately prior to implantation. Prospective, randomised, parallel-group, open-label study design in a single centre. One hundred and eighty-six androgen-deficient men (400 implantation procedures) were randomised into either a group who had their pellets soaked for approximately 2 min in gentamicin solution prior to implantation, or a control group who had the standard implantation procedure. Extrusion, infection and/or bruising were evaluated prospectively by self-report from the participants, and retrospectively at subsequent implantation. Other variables (site, shaving, skin preparation, operator, pellet batch, bruising) were collected at implantation time. The extrusion rate was 20% lower (odds ratio=0.80, 95% confidence interval (CI) 0.40-1.62) but not statistically different between the two groups (extrusion rate 23/205 (11.2%) for the control group vs 18/195 (9.2%) for the antibiotic-soak group, P=0.42). One operator...Continue Reading

Citations

Sep 28, 2005·Treatments in Endocrinology·Emily Darby, Bradley D Anawalt
Jan 14, 2012·The Journal of Sexual Medicine·Andrew R McCulloughLaurence A Levine
Mar 31, 2004·Clinical Endocrinology·S KelleherD J Handelsman
May 21, 2010·Expert Opinion on Pharmacotherapy·Anthony Yin, Ronald Swerdloff
Aug 27, 2004·Drugs·Louis J G Gooren, Mathijs C M Bunck
Jan 1, 2014·Current Sexual Health Reports·Andrew McCullough

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