A randomised controlled study of the reactogenicity of an acellular pertussis-containing pentavalent infant vaccine compared to a quadrivalent whole cell pertussis-containing vaccine and oral poliomyelitis vaccine, when given concurrently with meningococcal group C conjugate vaccine to healthy UK infants at 2, 3 and 4 months of age

Vaccine
Nicholas KitchinE Miller

Abstract

Two hundred forty-one healthy infants were enrolled in an open randomised controlled study of three doses of DTaP-IPV-Hib (Group 1) or DTwP/Hib+OPV (Group 2) at 2, 3 and 4 months of age given concurrently with a meningitis C conjugate vaccine. After each dose, local reactions (any grade) were less common in Group 1 than Group 2 (p<0.03). Axillary temperature >37.5 degrees C, decreased feeding, reduced activity, irritability and crying in the week after vaccination were also less common in Group 1 than Group 2 (p<0.05 for each symptom, all doses combined). Severe local reactions and systemic symptoms were uncommon and occurred equally in both groups. The pentavalent DTaP-IPV-Hib vaccine was less reactogenic than the quadrivalent DTwP-Hib vaccine, as expected when changing from whole cell pertussis (wP) to an acellular pertussis (aP) component.

References

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Citations

Dec 23, 2006·Archives of Disease in Childhood·A J Pollard
Oct 18, 2011·Paediatric Drugs·James E Frampton
Mar 14, 2007·Current Opinion in Neurology·Natasha J BrownIngrid E Scheffer
Feb 18, 2012·Clinical and Vaccine Immunology : CVI·Lucia H Lee, Milan S Blake
Nov 8, 2007·Paediatric Anaesthesia·Natasha S Crowcroft, David Elliman
Sep 15, 2012·The Journal of Advanced Prosthodontics·Sonune Shital JalandarVaidya Smita
Oct 26, 2021·The Cochrane Database of Systematic Reviews·Gladymar Perez ChaconTom Snelling

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