Abstract
Two hundred forty-one healthy infants were enrolled in an open randomised controlled study of three doses of DTaP-IPV-Hib (Group 1) or DTwP/Hib+OPV (Group 2) at 2, 3 and 4 months of age given concurrently with a meningitis C conjugate vaccine. After each dose, local reactions (any grade) were less common in Group 1 than Group 2 (p<0.03). Axillary temperature >37.5 degrees C, decreased feeding, reduced activity, irritability and crying in the week after vaccination were also less common in Group 1 than Group 2 (p<0.05 for each symptom, all doses combined). Severe local reactions and systemic symptoms were uncommon and occurred equally in both groups. The pentavalent DTaP-IPV-Hib vaccine was less reactogenic than the quadrivalent DTwP-Hib vaccine, as expected when changing from whole cell pertussis (wP) to an acellular pertussis (aP) component.
References
Feb 8, 1996·The New England Journal of Medicine·L GustafssonJ Storsaeter
Jan 1, 1997·Vaccine·E MillerT Coleman
Dec 11, 1997·Lancet·P OlinH Heijbel
Dec 22, 1999·Biologicals : Journal of the International Association of Biological Standardization·E Miller
Jan 5, 2002·Pediatrics·Paul A OffitSarah Landry
Feb 25, 2003·Archives of Disease in Childhood·E MillerB Taylor
Nov 5, 2003·Pediatrics·Nicole Le SauxUNKNOWN Canadian Paediatric Society/ Health Canada Immunization Monitoring Program-Active (IMPACT)
Aug 24, 2004·BMJ : British Medical Journal·Helen Bedford, David Elliman
Citations
May 31, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·U BeyazovaA Duyan Camurdan
May 4, 2006·Archives of Disease in Childhood·N R E KitchinE Miller
Dec 23, 2006·Archives of Disease in Childhood·A J Pollard
Dec 17, 2011·The Pediatric Infectious Disease Journal·Joanne M LangleyBruce Smith
Oct 18, 2011·Paediatric Drugs·James E Frampton
Mar 14, 2007·Current Opinion in Neurology·Natasha J BrownIngrid E Scheffer
Aug 30, 2013·Expert Review of Vaccines·Natalie G Martin, Matthew D Snape
Jun 14, 2012·Vaccine·Reinhard BernerDonna Reynolds
Jul 4, 2009·Vaccine·Nicholas KitchinElizabeth Miller
Jan 27, 2009·Vaccine·Eva Maria PöllabauerHartmut J Ehrlich
May 22, 2007·Vaccine·Susanna EspositoNicola Principi
Aug 3, 2011·Vaccine·Emmanuel GrimprelDonna Reynolds
Aug 31, 2010·Vaccine·Nick AndrewsElizabeth Miller
Apr 6, 2017·Immunological Investigations·Carlos Espinosa-ViñalsVicente Vérez Bencomo
Feb 18, 2012·Clinical and Vaccine Immunology : CVI·Lucia H Lee, Milan S Blake
Aug 24, 2013·Clinical and Vaccine Immunology : CVI·Timo VesikariDonna Reynolds
Jun 10, 2016·Clinical and Vaccine Immunology : CVI·Michael P BroderickDennis J Faix
Nov 8, 2007·Paediatric Anaesthesia·Natasha S Crowcroft, David Elliman
Jul 6, 2014·Expert Review of Vaccines·Donna L Reynolds, Emmanuel Vidor
Sep 15, 2012·The Journal of Advanced Prosthodontics·Sonune Shital JalandarVaidya Smita
May 21, 2020·Vaccines·Eleonora E LambertCécile A C M van Els
Oct 26, 2021·The Cochrane Database of Systematic Reviews·Gladymar Perez ChaconTom Snelling