A randomised controlled trial comparing GnRH antagonist cetrorelix with GnRH agonist leuprorelin for endometrial thinning prior to transcervical resection of endometrium

BJOG : an International Journal of Obstetrics and Gynaecology
K BhatiaB Bentick

Abstract

To compare the effectiveness of leuprorelin and cetrorelix, when used as preoperative endometrial thinning agents prior to transcervical resection of endometrium (TCRE). A prospective, double-blind randomised controlled trial. Gynaecological department of a UK district general hospital. A total of 106 premenopausal women with dysfunctional uterine bleeding, undergoing TCRE. Women were equally randomised to 3.75 mg of leuprorelin acetate (3-4 weeks) or 3 mg cetrorelix (4-7 days) prior to TCRE. About 1 ml saline was given as placebo in both arms. Amenorrhoea rate at 6 months, endometrial thickness using transvaginal ultrasound on the day of operation. A total of 100 women completed the trial with no loss to follow up. Amenorrhoea rate at 6 months after surgery was high in both groups (80% cetrorelix and 84% leuprorelin) with no statistical significance. All endometrial outcome measures including endometrial thickness on ultrasound, histology and operative appearance were more favourable in leuprorelin group as compared with cetrorelix (P values 0.013, <0.001 and 0.003 respectively). More women in leuprorelin group had hot flushes as compared with cetrorelix (15/50 versus 6/50; P = 0.047). No significant differences were seen in o...Continue Reading

References

Jul 1, 1995·Obstetrics and Gynecology·R Garry
Jan 1, 1994·Annual Review of Medicine·P M Conn, W F Crowley
Apr 1, 1996·British Journal of Obstetrics and Gynaecology·R GarryM Stuart
Nov 18, 1997·Human Reproduction·D Gonzalez-BarcenaH Riethmüller-Winzen
Dec 6, 2001·Lancet·J A Huirne, C B Lambalk
Mar 17, 2004·Complementary Therapies in Medicine·Eric Manheimer, Brian Berman
Oct 20, 2005·The Cochrane Database of Systematic Reviews·A LethabyR Garry

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Citations

Oct 18, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rodolfo RoblesMaria R Guerrero
Apr 9, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jo KitawakiIzumi Suganuma
Mar 17, 2010·Journal of Minimally Invasive Gynecology·Jong Ha HwangKyu Wan Lee
Nov 16, 2013·The Cochrane Database of Systematic Reviews·Yu Hwee Tan, Anne Lethaby
Apr 20, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Russ DeLonzorJoseph J Williams

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