Abstract
Obesity and type 2 diabetes are inextricably linked. It is therefore unfortunate that insulin, the ultimate treatment to improve glycaemic control in type 2 diabetes, is associated with significant weight gain. The aim of the present investigation was to ascertain whether a dietitian-led intensive lifestyle intervention could attenuate weight gain associated with commencing insulin therapy. Subjects (n 50) with type 2 diabetes, within 4 weeks of starting insulin therapy, were randomly allocated to a control or intervention group. The control group continued with standard care whilst the intervention group followed a dietitian-led intensive lifestyle intervention. Over 6 months the control group gained 4.9 (sd 3.6) kg (P < 0.001), whilst the intervention group maintained their weight ( - 0.6 (sd 5.1) kg (NS). The difference in weight change between the groups was 5.5 kg (P < 0.001). The control group had significant increases whilst the intervention group had slight decreases in: BMI (+1.7 (sd 1.3) kg/m2 (P < 0.001) v. - 0.3 (sd 2.0) kg/m2 (NS)), waist circumference (+5.3 (sd 5.0) cm (P < 0.001) v. - 0.4 (sd 5.2) cm (NS)) and percentage body fat (+1.5 (sd 2.0) % (P < 0.001) v. - 0.4 (sd 2.8) % (NS)). Differences between the grou...Continue Reading
References
Nov 1, 1990·Postgraduate Medical Journal·G Wannamethee, A G Shaper
Feb 8, 1995·JAMA : the Journal of the American Medical Association·W C WillettC H Hennekens
Feb 1, 1995·Diabetes Care·R Klein
Jan 14, 1995·BMJ : British Medical Journal
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Dec 23, 1995·BMJ : British Medical Journal·J S Garrow
Jan 1, 1996·Annals of Internal Medicine·R TurnerR Holman
Jan 26, 1999·JAMA : the Journal of the American Medical Association·M H DavidsonS B Heymsfield
Nov 29, 2001·Clinical Science·R J StevensUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Astrup, N Finer
Aug 3, 2002·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·G FrostA Dornhorst
Nov 28, 2002·Diabetes Care·UNKNOWN Diabetes Prevention Program (DPP) Research Group
Dec 28, 2002·Diabetes Care·Saul GenuthUNKNOWN American Diabetes Association
Jun 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S AshS Capra
Nov 25, 2003·Diabetes Care·Saul Genuth
Aug 13, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M Davies
Sep 24, 2004·Annals of Internal Medicine·Elizabeth SelvinSherita Hill Golden
Apr 22, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·R N GuzderC D Byrne
May 3, 2005·Gastroenterology Clinics of North America·George F Longstreth
Dec 16, 2005·The American Journal of the Medical Sciences·Efrain Reisin, Martin A Alpert
Mar 6, 2007·Lancet·Lorraine L Lipscombe, Janet E Hux
Citations
May 4, 2011·Psychosomatic Medicine·Kenneth E FreedlandJoseph E Schwartz
Jun 8, 2011·Diabetes, Obesity & Metabolism·A E PontiroliA Morabito
Jan 16, 2009·International Journal of Clinical Practice·A BarnettN Munro
Jul 10, 2014·Metabolic Syndrome and Related Disorders·Kerry K McMillenMerav Bar
Aug 6, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K KempfS Martin
May 1, 2016·Internal Medicine Journal·R Yadgar-YaldaJ M Wentworth
Apr 1, 2012·Journal of Primary Care & Community Health·John-Michael GamblePeter A Senior
May 17, 2017·Diabetes, Obesity & Metabolism·Adrian BrownGary Frost
Oct 11, 2013·Diabetes Care·Alison B EvertUNKNOWN American Diabetes Association
Dec 21, 2013·Diabetes Care·Alison B EvertWilliam S Yancy
Feb 27, 2019·The Journal of Nursing Research : JNR·Hui-Chun HsuLing-Wang An
Jul 1, 2015·The Cochrane Database of Systematic Reviews·Aslak SteinsbekkAtle Fretheim
Nov 24, 2016·Diabetes Care·Margaret A Powers
Apr 27, 2021·Obesity·Li DingMing Liu
Oct 19, 2020·Journal of the Academy of Nutrition and Dietetics·Feon W ChengDeepa Handu
Jul 27, 2021·International Journal of Clinical Practice·Wei LiangKa Ming Chow
Sep 29, 2015·Annals of Internal Medicine·Jennifer PillayDonna M Dryden