A randomised controlled trial of a brief cognitive behavioural intervention for men who have hot flushes following prostate cancer treatment (MANCAN)

Psycho-oncology
Evgenia StefanopoulouMyra S Hunter

Abstract

Hot flushes and night sweats (HFNS) are experienced by up to 80% of prostate cancer patients undergoing androgen deprivation therapy (ADT). This study evaluates the effects of a guided self-help cognitive behavioural therapy (CBT) intervention on HFNS problem-rating (primary outcome), HFNS frequency, mood and health-related quality of life (secondary outcomes) in patients undergoing ADT. Patients reporting treatment-induced HFNS were randomly assigned to CBT (n = 33) or treatment as usual (TAU) (n = 35), stratified for cancer type. The CBT intervention included a booklet, CD plus telephone contact during a 4-week period. Validated self-report questionnaires were completed at baseline, 6 weeks and 32 weeks after randomisation. The primary outcome was HFNS problem rating (perceived burden of HFNS) at 6 weeks after randomisation. Potential moderators and mediators were examined. Data analysis was conducted on a modified intention-to-treat basis. Compared with TAU, CBT significantly reduced HFNS problem rating (adjusted mean difference: -1.33, 95% CI -2.07 to -0.58; p = 0.001) and HFNS frequency (-12.12, 95% CI -22.39 to -1.84; p = 0.02) at 6 weeks. Improvements were maintained at 32 weeks, but group differences did not reach signi...Continue Reading

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Citations

Dec 18, 2015·Climacteric : the Journal of the International Menopause Society·M S Hunter, E Stefanopoulou
Jun 7, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·D R FenlonM S Hunter
Mar 25, 2019·Climacteric : the Journal of the International Menopause Society·M S HunterD Fenlon
Dec 14, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Maud J M GeerkensHarry P Beerlage
Jun 9, 2021·British Journal of Health Psychology·Myra S Hunter, Joseph Chilcot

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Methods Mentioned

BETA
cognitive behavioural therapy

Software Mentioned

MANCAN
Rand
exe

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