A randomised controlled trial of early versus delayed oxytocin augmentation to treat primary dysfunctional labour in nulliparous women

BJOG : an International Journal of Obstetrics and Gynaecology
K HinshawJ Thornton

Abstract

Oxytocin is widely used to speed up slow labour, especially in nulliparous women, but randomised trials, apart from one reported only in abstract, have been too small to exclude important effects. To test the hypothesis that early use of oxytocin reduces the need for caesarean delivery. A randomised controlled trial. Twelve obstetric units within the Northern and Yorkshire regions in the North East of England. A total of 412 low-risk nulliparous women in spontaneous labour at term, who had been diagnosed with primary dysfunctional labour were recruited from January 1999 to December 2001. Immediate oxytocin administration (active group) or oxytocin withheld for up to 8 hours (conservative group). Caesarean section and operative vaginal delivery rates. The length of labour measured from the time of randomisation to delivery. The rate of maternal Edinburgh Postnatal Depression Scale (EPDS) greater than 12 (major depression) within 48 hours of delivery. The caesarean section rates were 13.5% active versus 13.7% controls (OR 0.98, 95% CI 0.6-1.7). Operative delivery, 24.5% versus 30.9% (OR 0.73, 95% CI 0.5-1.1). The median (interquartile range) randomisation to delivery interval in the active group was 5 hours 52 minutes (3:57-8:28)...Continue Reading

References

Jun 1, 1987·British Journal of Obstetrics and Gynaecology·K A Bidgood, P J Steer
Jun 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·J L CoxR Sagovsky
Oct 1, 1987·Research in Nursing & Health·E D Hodnett, D A Simmons-Tropea
Oct 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E HemminkiL Henriksson
May 24, 1969·British Medical Journal·K O'DriscollJ T Gallagher
Jan 1, 1980·Irish Journal of Medical Science·J O'HareN Callaghan
Sep 21, 1995·The New England Journal of Medicine·F D FrigolettoS Datta
Aug 6, 1994·BMJ : British Medical Journal·J G Thornton, R J Lilford
Jan 27, 1998·British Journal of Obstetrics and Gynaecology·G BlanchZ Alfirevic
Mar 21, 1998·British Journal of Obstetrics and Gynaecology·W FraserG Bréart
May 5, 2000·The Cochrane Database of Systematic Reviews·W D FraserG Brisson-Carrol
Nov 3, 2005·JAMA : the Journal of the American Medical Association·Victor M MontoriGordon H Guyatt

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Citations

Aug 25, 2009·Obstetrics and Gynecology·Shu-Qin WeiWilliam D Fraser
Nov 19, 2013·Brain Research·Sohye KimLane Strathearn
Nov 18, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Janne RossenTorbjørn Moe Eggebø
May 15, 2012·Sexual & Reproductive Healthcare : Official Journal of the Swedish Association of Midwives·Liselotte BergqvistMarie Berg
Jan 7, 2016·Harvard Review of Psychiatry·Beth L Mah
Aug 27, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·P BorI Stornes
Jul 18, 2014·BMC Pregnancy and Childbirth·Astrid Nystedt, Ingegerd Hildingsson
Jan 31, 2017·Depression and Anxiety·Aimee R Kroll-DesrosiersKristina M Deligiannidis
Jul 13, 2013·The Cochrane Database of Systematic Reviews·Philippa L Costley, Christine E East
Sep 23, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·P J Teoh
Feb 7, 2020·Health Care for Women International·Melek Balcik Colak, Hafize Ozturk Can
Feb 18, 2016·Journal of Perinatal Medicine·Angela P H BurgessNisha A Lakhi
Jun 25, 2013·The Cochrane Database of Systematic Reviews·George J BuggJim G Thornton
Sep 18, 2013·The Cochrane Database of Systematic Reviews·Heather C BrownJane Thomas
Aug 1, 2020·Clinical Obstetrics and Gynecology·Calla Holmgren
Jan 15, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Vasilios PergialiotisGeorge Daskalakis
Nov 12, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Lotta SelinAnna Dencker

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