PMID: 11905429Mar 22, 2002Paper

A randomised controlled trial of intramuscular syntometrine and intravenous oxytocin in the management of the third stage of labour

BJOG : an International Journal of Obstetrics and Gynaecology
C M Y ChoyP M Yuen

Abstract

To compare the efficacy and safety of intravenous oxytocin with intramuscular syntometrine in the management of the third stage of labour. A prospective randomised trial. A university teaching hospital. A total of 991 women having a singleton pregnancy and vaginal delivery were randomised by a computer-generated number to receive either 1 ml syntometrine intramuscularly or 10 units of intravenous Syntocinon after delivery of the anterior shoulder of the fetus. Blood loss during delivery, rate of postpartum haemorrhage, need for repeated oxytocics, haemoglobin level before and 24 hours after delivery, duration of third stage, need for manual removal of placenta and sides effects including hypertension, nausea, vomiting, headache and chest pain. The use of intravenous oxytocin was associated with a reduction in postpartum blood loss (P < 0.001) but there was no difference in the risk of postpartum haemorrhage in the need for repeated oxytocic injections and the drop in peripartum haemoglobin level between the two groups. There was also no difference in the risk of prolonged third stage, or in the need for manual removal of placenta. The use of syntometrine was associated with a higher risk of hypertension (RR 2.39, 95% CI 1.00-5....Continue Reading

References

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Citations

Mar 17, 2004·Current Opinion in Obstetrics & Gynecology·Yap-Seng ChongSabaratnam Arulkumaran
Jul 16, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M RashidM H Rashid
Dec 22, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R Lourens, S Paterson-Brown
Jul 21, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Werner Rath
Jan 1, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ernest OrjiOladapo Olaleye
Dec 21, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·S W LeungT H Cheung
Sep 7, 2016·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Edward SpringhallMiranda Davies-Tuck
Sep 25, 2018·The Cochrane Database of Systematic Reviews·Olufemi T OladapoEdgardo Abalos
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Feb 20, 2004·The Cochrane Database of Systematic Reviews·S McDonaldS P Higgins
Mar 23, 2004·Archives of Gynecology and Obstetrics·J B SharmaR Arora
Mar 13, 2014·Iranian Red Crescent Medical Journal·Mansoureh SamimiMasoumeh Abedzadeh-Kalahroudi
Apr 26, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Jun 21, 2007·The Journal of Obstetrics and Gynaecology Research·Keisuke SaitoFumiki Hirahara
Jul 15, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Robabeh TaheripanahNarges Malih
Mar 2, 2019·Health Technology Assessment : HTA·Ioannis GallosArri Coomarasamy

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