A randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia

British Journal of Obstetrics and Gynaecology
E J CoetzeeJ Anthony

Abstract

To determine whether the administration of prophylactic intravenous magnesium sulphate reduces the occurrence of eclampsia in women with severe pre-eclampsia. Randomised controlled trial. A tertiary referral obstetric unit. Eight hundred and twenty-two women with severe pre-eclampsia requiring termination of pregnancy by induction of labour or caesarean section. The women were randomised to receive either placebo (saline) or magnesium sulphate intravenously. The investigators were blinded to the contents of the pre-mixed solutions. The occurrence of eclampsia in the two groups. The data of 699 women were evaluated. Fourteen were withdrawn after randomisation. The overall incidence of eclampsia was 1.8%. Of 345 women who received magnesium sulphate, one developed eclampsia (0.3%); in the placebo group, 11/340 women (3.2%) developed eclampsia (relative risk 0.09; 95% confidence interval 0.01-0.69; P = 0.003). The use of intravenous magnesium sulphate in the management of women with severe pre-eclampsia significantly reduced the development of eclampsia.

References

Feb 1, 1990·British Journal of Obstetrics and Gynaecology·C Crowther
May 1, 1990·American Journal of Obstetrics and Gynecology·B M Sibai
Feb 1, 1990·British Journal of Obstetrics and Gynaecology·J Dommisse
Apr 30, 1988·British Medical Journal·C W Redman
Apr 1, 1984·American Journal of Obstetrics and Gynecology·J A PritchardS A Pritchard
Jul 27, 1995·The New England Journal of Medicine·M J LucasF G Cunningham
Jul 27, 1995·The New England Journal of Medicine·J M Roberts
Jul 1, 1994·British Journal of Obstetrics and Gynaecology·L Duley, R Johanson

❮ Previous
Next ❯

Citations

Aug 29, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Laurent Dubé, Jean-Claude Granry
Sep 12, 2000·Current Hypertension Reports·R ShearJ M Moutquin
Aug 5, 2003·Current Treatment Options in Neurology·Michael A. Sloan, Barney J. Stern
Nov 28, 2012·International Journal of Obstetric Anesthesia·C Dean, J Douglas
Jan 9, 2003·Obstetrics and Gynecology·Christy M IslerJames N Martin
Feb 11, 2003·Obstetrics and Gynecology·Jeffrey C LivingstonBaha M Sibai
Jul 10, 2003·Obstetrics and Gynecology·William W HurdAdrienne Stolfi
Jul 10, 2003·Obstetrics and Gynecology·Baha M Sibai
Oct 30, 1998·Obstetrics and Gynecology·A G Witlin, B M Sibai
Jan 23, 2003·Molecular Aspects of Medicine·R M Touyz
Nov 5, 2002·Lancet·Baha M Sibai
Jun 14, 2003·Current Problems in Cardiology·John M FlackSamar A Nasser
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A C BolteG A Dekker
Jan 24, 2003·The New England Journal of Medicine·Michael A BelfortUNKNOWN Nimodipine Study Group
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·D O Anumba, S C Robson
Aug 19, 1999·Clinical Obstetrics and Gynecology·A G Witlin
Jun 6, 2002·Clinical Obstetrics and Gynecology·Errol R NorwitzJohn T Repke
Feb 24, 2005·Clinical Obstetrics and Gynecology·Kjersti M Aagaard-Tillery, Michael A Belfort
Apr 5, 2005·Clinical Obstetrics and Gynecology·Baha M Sibai
Sep 19, 2006·Obstetrical & Gynecological Survey·Michael A BelfortBaha Sibai
Jul 20, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·J G Thornton
Jul 20, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·D R HallM Smith
Dec 8, 2006·Seminars in Dialysis·Andrew R Haas, Paul E Marik
Feb 7, 2013·BMC Pregnancy and Childbirth·Jeffrey Michael SmithErica Felker-Kantor
Apr 29, 2011·BMC Public Health·Mehnaz JabeenZulfiqar A Bhutta
May 10, 2000·Clinical Pharmacokinetics·J F Lu, C H Nightingale
Jul 28, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·M B GreenbergD J Lyell
Sep 15, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Maryam KashanianSara Asadolla
Nov 4, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jinyoung HwangSunghee Han
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nora M GrahamVincenzo Berghella
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Jimmy Espinoza
Jun 15, 2007·Chest·Paul E Marik, Joseph Varon
Jul 14, 2000·Chest·J Varon, P E Marik
May 25, 2010·Epilepsy & Behavior : E&B·Susan W Lee, Steve S Chung
Mar 8, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Lelia Duley
Jul 31, 2010·Acta Clinica Belgica·G BrichantJ F Brichant
Jan 5, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Maria J SmallKeith P Williams
Apr 22, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Scott A ShainkerKaren O'Brien
Jan 22, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·L A Magee
May 22, 2013·Journal of Pregnancy·Mauro H SchenoneGiancarlo Mari
Jun 16, 1999·American Journal of Obstetrics and Gynecology·S E SzalS J Kilpatrick
May 23, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·L A Magee
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·L DuleyJ P Neilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved