A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial.

Health Technology Assessment : HTA
Janesh GuptaECLIPSE Collaborative Group

Abstract

Heavy menstrual bleeding (HMB) is a common problem, yet evidence to inform decisions about initial medical treatment is limited. To assess the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system (LNG-IUS) (Mirena®, Bayer) compared with usual medical treatment, with exploration of women's perspectives on treatment. A pragmatic, multicentre randomised trial with an economic evaluation and a longitudinal qualitative study. Women who presented in primary care. A total of 571 women with HMB. A purposeful sample of 27 women who were randomised or ineligible owing to treatment preference participated in semistructured face-to-face interviews around 2 and 12 months after commencing treatment. LNG-IUS or usual medical treatment (tranexamic acid, mefenamic acid, combined oestrogen-progestogen or progesterone alone). Women could subsequently swap or cease their allocated treatment. The primary outcome was the patient-reported score on the Menorrhagia Multi-Attribute Scale (MMAS) assessed over a 2-year period and then again at 5 years. Secondary outcomes included general quality of life (QoL), sexual activity, surgical intervention and safety. Data were analysed using iterative constant compari...Continue Reading

References

Feb 1, 1991·The Australian & New Zealand Journal of Obstetrics & Gynaecology·I S Fraser, G McCarron
May 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J M Higham, R W Shaw
Nov 1, 1984·Medical Care·M H Boyle, G W Torrance
Jan 1, 1995·International Journal of Technology Assessment in Health Care·A CoulterM C Rees
May 1, 1994·Epidemiology·S D Harlow, B C Campbell
May 29, 1993·BMJ : British Medical Journal·A M GarrattI T Russell
Aug 1, 1995·The Australian & New Zealand Journal of Obstetrics & Gynaecology·R AhujaD Takkar
Oct 1, 1996·Critical Care Medicine·R Brooks
Feb 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·K ThirlawayJ Cuzick
May 7, 1998·BMJ : British Medical Journal·A Prentice
Aug 6, 1998·British Journal of Obstetrics and Gynaecology·D L LampingL Lessof
Dec 16, 1998·British Journal of Obstetrics and Gynaecology·R W ShawM J Edwards
Aug 6, 1995·Quality in Health Care : QHC·A CoulterT A Sheldon
Apr 7, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J M Higham, R W Shaw
Jun 3, 1999·Journal of Advanced Nursing·A Chapple
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·M L SteadJ M Brown
Feb 5, 2000·Social Science & Medicine·N O'Flynn, N Britten
Feb 24, 2001·Archives of Gynecology and Obstetrics·T TabataT Yabana
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A StewartW Phillips
Mar 23, 2001·American Journal of Obstetrics and Gynecology·W K NicholsonN R Powe
Sep 11, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E FrewD K Whynes
Sep 11, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T Justin ClarkJanesh K Gupta
Feb 5, 2003·Patient Education and Counseling·Sirkku VuormaErkki Kujansuu
Mar 8, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M ShapleyP R Croft
Apr 16, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Julian W BarringtonMohammed Abdel-Fattah
Apr 30, 2003·Health Economics·Andrew BriggsPhilip Clarke
Jun 12, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Mark ShapleyPeter R Croft
Jun 27, 2003·Drugs·Keri Wellington, Antona J Wagstaff
Mar 25, 2004·JAMA : the Journal of the American Medical Association·Miriam KuppermannUNKNOWN Ms Research Group

❮ Previous
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Citations

Jun 11, 2016·European Heart Journal·Chris P Gale, Héctor Bueno
Sep 21, 2016·Obstetrics and Gynecology International·Luis BahamondesMaria Y Makuch
Sep 25, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Lion ShahabLinda Bauld
Jun 9, 2016·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Ian LitchfieldSheila Greenfield
Dec 13, 2017·Cold Spring Harbor Perspectives in Medicine·Giorgia Zadra, Massimo Loda
Dec 5, 2018·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Jane VennikMichael Moore
Dec 19, 2018·Blood·Marzia Menegatti, Flora Peyvandi
Jul 13, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Raffaele Scala, Lara Pisani
Oct 13, 2016·ERJ Open Research·William D-C ManSally J Singh
Aug 6, 2016·The European Respiratory Journal·Lauri LehtimäkiAnneli Ahovuo-Saloranta
Jan 18, 2018·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Kathrine Gibson SmithDerek Stewart
Jun 20, 2018·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Adam MartinJuliet A Usher-Smith
May 18, 2019·Future Healthcare Journal·Terry YoungSada Soorapanth
Dec 9, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Kartik Kumar, Ibrahim Abubakar
Feb 20, 2019·Cell and Tissue Research·Muris HumoIpek Yalcin
Jan 18, 2020·The European Respiratory Journal·Andrew Menzies-GowChristopher E Brightling
Apr 18, 2018·BMJ Global Health·Jessica OchalekKarl Claxton
Oct 20, 2018·British Journal of Sports Medicine·Margie H DavenportMichelle F Mottola
Oct 20, 2018·British Journal of Sports Medicine·Margie H DavenportStephanie-May Ruchat
Apr 24, 2018·The British Journal of Ophthalmology·Noha SharafeldinKarim F Damji
Aug 9, 2017·Emergency Medicine Journal : EMJ·Richard Body, Edward Carlton
Feb 12, 2020·BMJ Quality & Safety·Helen HandollAmar Rangan
May 4, 2018·Emergency Medicine Journal : EMJ·Robert M RodriguezBrigitte M Baumann
Nov 30, 2019·BMJ Quality & Safety·Katharine ReevesRichard J Lilford
Aug 23, 2019·Postgraduate Medical Journal·Mueez WaqarPeter J Hutchinson
Feb 19, 2019·BMJ Global Health·Julian P T HigginsDeborah M Caldwell

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