A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease

BMC Medicine
Miriam J JohnsonSara Booth

Abstract

About 90 % of patients with intra-thoracic malignancy experience breathlessness. Breathing training is helpful, but it is unknown whether repeated sessions are needed. The present study aims to test whether three sessions are better than one for breathlessness in this population. This is a multi-centre randomised controlled non-blinded parallel arm trial. Participants were allocated to three sessions or single (1:2 ratio) using central computer-generated block randomisation by an independent Trials Unit and stratified for centre. The setting was respiratory, oncology or palliative care clinics at eight UK centres. Inclusion criteria were people with intrathoracic cancer and refractory breathlessness, expected prognosis ≥3 months, and no prior experience of breathing training. The trial intervention was a complex breathlessness intervention (breathing training, anxiety management, relaxation, pacing, and prioritisation) delivered over three hour-long sessions at weekly intervals, or during a single hour-long session. The main primary outcome was worst breathlessness over the previous 24 hours ('worst'), by numerical rating scale (0 = none; 10 = worst imaginable). Our primary analysis was area under the curve (AUC) 'worst' from b...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Oct 1, 1996·Palliative Medicine·J CornerC Bailey
Jun 17, 1999·Allergy·M Branco FerreiraA G Palma Carlos
Feb 25, 2000·Journal of Pain and Symptom Management·P EdmondsM McDonnell
Jul 10, 2003·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Matthew Johnson, Sally Moore
Jan 11, 2005·The European Respiratory Journal·H J SchünemannG H Guyatt
Feb 26, 2005·BMJ : British Medical Journal·Susan Mayor
Aug 23, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lucie KutikovaWilliam H Crown
Jan 1, 1997·International Journal of Behavioral Medicine·C S Carver
Nov 18, 2005·Psycho-oncology·Jiong Li, Afaf Girgis
Nov 23, 2006·Respiration; International Review of Thoracic Diseases·Andreas von LeupoldtBernhard Dahme
Aug 19, 2008·Respiratory Physiology & Neurobiology·Robert W LansingRobert B Banzett
Sep 10, 2008·Archives of Internal Medicine·R Sean MorrisonUNKNOWN Palliative Care Leadership Centers' Outcomes Group
Feb 9, 2010·Emergency Medicine Australasia : EMA·Amanda SaracinoAndrew W Dent
Apr 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rachael BartonMiriam J Johnson
Feb 1, 2009·Expert Review of Respiratory Medicine·Sara BoothShakeeb H Moosavi
Sep 8, 2010·The New England Journal of Medicine·Jennifer S TemelThomas J Lynch
Feb 15, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C L GrangerL Denehy
Dec 14, 2011·Asia-Pacific Journal of Clinical Oncology·Stephen Ackland
Apr 24, 2013·Journal of Pain and Symptom Management·Miriam J JohnsonDavid C Currow
Aug 1, 2013·BMC Medical Research Methodology·Brennan C Kahan, Tim P Morris
Oct 17, 2013·American Journal of Respiratory and Critical Care Medicine·Martijn A SpruitUNKNOWN ATS/ERS Task Force on Pulmonary Rehabilitation

❮ Previous
Next ❯

Citations

Jan 26, 2016·Expert Review of Respiratory Medicine·Miriam J Johnson, David C Currow
May 16, 2017·Palliative Medicine·Miriam J JohnsonDavid C Currow
Jun 22, 2018·Current Opinion in Supportive and Palliative Care·Claudia BauseweinAnna Bolzani
May 27, 2017·The European Respiratory Journal·Miriam J JohnsonDavid C Currow
Dec 31, 2015·Current Opinion in Supportive and Palliative Care·Miriam J Johnson, Andrew L Clark
Jul 6, 2016·Current Opinion in Supportive and Palliative Care·Sara BoothAnna Spathis
Apr 10, 2020·NPJ Primary Care Respiratory Medicine·Tim LuckettJohn R Wheatley
Sep 2, 2017·British Journal of Community Nursing·Lucy Speakman, Helen Walthall
Feb 23, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David HuiMargaret L Campbell
Apr 23, 2021·Journal of Hospice and Palliative Nursing : JHPN : the Official Journal of the Hospice and Palliative Nurses Association·Margaret L CampbellLynn F Reinke
Sep 14, 2021·The American Journal of Hospice & Palliative Care·Rachel A Zemel
Aug 5, 2018·Journal of Pain and Symptom Management·Yvette S ZengAnne L Hume

❮ Previous
Next ❯

Clinical Trials Mentioned

ISRCTN49387307

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.