A randomised controlled trial to investigate the use of high-frequency airway oscillations as training to improve dyspnoea in COPD

ERJ Open Research
Enya DaynesSally J Singh

Abstract

Chronic obstructive pulmonary disease (COPD) is characterised by expiratory flow limitation resulting in symptomatic dyspnoea, sputum retention and ventilation heterogeneity. Changes in breathing mechanics affect the ability of respiratory muscles to respond to the ventilatory demands, increasing the sensation of dyspnoea. A high-frequency airway oscillating device has been developed to combine respiratory muscle training and oscillations to improve dyspnoea and sputum retention within COPD. Patients with symptomatic COPD (Medical Research Council Breathlessness scale grade ≥2) will be recruited to a double-blind, randomised, sham-controlled trial. Both groups will follow an 8-week intervention phase using the device three times per day for 5 min at a time. This will be recorded in a self-reported diary. The device applies a flow resistive load and oscillations for combined training. Those receiving the sham device will follow the same protocol; however, the mechanism of action will be removed from the device. Improvements in the Chronic Respiratory Questionnaire-Dyspnoea domain will be the primary outcome measure. Secondary outcomes will explore respiratory muscle function, health-related quality of life, exercise capacity and...Continue Reading

References

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Citations

Apr 17, 2020·The Cochrane Database of Systematic Reviews·Angela T BurgeAnne E Holland

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Clinical Trials Mentioned

ISRCTN45695543

Software Mentioned

ActiLife
ActiGraph
MATLAB

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