A Randomised, Double-Blind, Placebo-Controlled Trial of As-Needed Naltrexone in the Treatment of Pathological Gambling

European Addiction Research
Leena KovanenTuuli Lahti

Abstract

Effective treatment strategies are needed for the treatment of pathological gambling (PG). The efficacy of as-needed naltrexone was assessed in a single-centre, randomised, double-blind, placebo-controlled trial. The participants (n = 101) received either as-needed placebo or naltrexone (50 mg) and psychosocial support for 20 weeks. The primary outcome measure was the severity of PG assessed by the Yale-Brown Obsessive Compulsive Scale adapted for PG (PG-YBOCS). Secondary gambling-related outcome measures included thoughts/urges and behaviour subscales of PG-YBOCS as well as the highest daily expenditure and gambling frequency. In addition, RAND-36 scales of emotional well-being and social functioning were used as outcomes. The results were analysed using the intention-to-treat principle and linear random effects modelling. No significant treatment group differences were found. In an exploratory analysis, emotional well-being increased in a subgroup of participants with AA genotype of opioid receptor, mu 1 (OPRM1) A118G polymorphism (p = 0.02). Overall, the as-needed naltrexone may not provide substantial additional benefit for PG patients receiving psychosocial support. Replication by larger scale studies is warranted to furth...Continue Reading

Citations

Jan 23, 2016·Expert Opinion on Pharmacotherapy·Marcelo Piquet-Pessôa, Leonardo F Fontenelle
Nov 25, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joonas MajuriValtteri Kaasinen
Sep 22, 2018·Journal of Behavioral Addictions·Sophie WardHenrietta Bowden-Jones
Dec 21, 2018·Journal of Gambling Studies·Martina GoslarAnton-Rupert Laireiter
Jan 14, 2020·Expert Opinion on Pharmacotherapy·Shane W KrausMarc N Potenza
May 4, 2017·Annals of General Psychiatry·Sam-Wook ChoiHyunChul Youn
Mar 15, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jarkko JohanssonMika Scheinin
Jul 28, 2019·Nature Reviews. Disease Primers·Marc N PotenzaSarah W Yip
Apr 30, 2020·International Journal of Molecular Sciences·Audrey VerhollemanMarie Grall-Bronnec
May 8, 2018·Annual Review of Clinical Psychology·Nancy M PetryMeredith K Ginley
May 27, 2017·Current Pain and Headache Reports·O J Michael Coppes, Christine N Sang
Dec 28, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jon E Grant, Samuel R Chamberlain
May 28, 2021·Patient Preference and Adherence·Virginia Perez-MaciaLorena Garcia-Fernandez

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