A randomised double-blind placebo-controlled trial comparing stepwise oral misoprostol with vaginal misoprostol for induction of labour

Tropical Doctor
Hilda YenuberiJiji E Mathews

Abstract

A comparison of induction of labour (IOL) using three doses of 25 µg vaginal misoprostol inserted at intervals of 4 h or more with a stepwise oral regime starting with 50 µg followed by two doses of 100 µg was studied in a double-blind placebo-controlled trial in a tertiary centre in South India. Primary outcome was vaginal delivery in 24 h. Significantly more women in the first group required oxytocin augmentation and a third dose of the drug than women in the second group. Uterine tachysystole and other maternal and neonatal complications were similar. Thus it is concluded that women induced with oral, as compared to vaginal misoprostol are more likely to labour without oxytocin.

References

Apr 1, 1997·Obstetrics and Gynecology·L Sanchez-RamosF L Gaudier
Jul 1, 1997·Obstetrics and Gynecology·M ZiemanP D Darney
Feb 25, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J E MathewsA George
Jan 4, 2001·The New England Journal of Medicine·A B GoldbergP D Darney
Oct 20, 2001·American Journal of Obstetrics and Gynecology·S A FisherG A Davies
Mar 5, 2005·American Journal of Obstetrics and Gynecology·Iris ColónM Mark Taslimi
Feb 4, 2006·BMJ : British Medical Journal·Jodie M DoddJeffrey S Robinson
Oct 27, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A WeeksD Wing
Jun 24, 2009·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists
Aug 21, 2012·American Journal of Obstetrics and Gynecology·Robert D StewartKenneth J Leveno
Mar 1, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·A W ShandC L Roberts

❮ Previous
Next ❯

Citations

Oct 23, 2020·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Behnaz SouiziMohammad Sahebkar
Jun 23, 2021·The Cochrane Database of Systematic Reviews·Robbie S KerrAndrew D Weeks

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BJOG : an International Journal of Obstetrics and Gynaecology
J S KwonV P Mackenzie
BJOG : an International Journal of Obstetrics and Gynaecology
N van GemundH H H Kanhai
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Pearlin R ChavakulaJiji E Mathews
© 2022 Meta ULC. All rights reserved