A randomised, double blind trial of N-Acetylcysteine for hearing protection during stapes surgery

PloS One
Dan Bagger-SjöbäckAnders Fridberger

Abstract

Otosclerosis is a disorder that impairs middle ear function, leading to conductive hearing loss. Surgical treatment results in large improvement of hearing at low sound frequencies, but high-frequency hearing often suffers. A likely reason for this is that inner ear sensory cells are damaged by surgical trauma and loud sounds generated during the operation. Animal studies have shown that antioxidants such as N-Acetylcysteine can protect the inner ear from noise, surgical trauma, and some ototoxic substances, but it is not known if this works in humans. This trial was performed to determine whether antioxidants improve surgical results at high frequencies. We performed a randomized, double-blind and placebo-controlled parallel group clinical trial at three Swedish university clinics. Using block-stratified randomization, 156 adult patients undergoing stapedotomy were assigned to intravenous N-Acetylcysteine (150 mg/kg body weight) or matching placebo (1:1 ratio), starting one hour before surgery. The primary outcome was the hearing threshold at 6 and 8 kHz; secondary outcomes included the severity of tinnitus and vertigo. One year after surgery, high-frequency hearing had improved 2.7 ± 3.8 dB in the placebo group (67 patients a...Continue Reading

Associated Clinical Trials

References

Aug 1, 1992·Clinical Otolaryngology and Allied Sciences·G G Browning, S Gatehouse
Jan 1, 1990·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·R A Tange, W A Dreschler
Jul 1, 1986·The Annals of Otology, Rhinology, and Laryngology·I W Mair, E Laukli
Jan 1, 1986·European Journal of Clinical Pharmacology·L BorgströmO Paulsen
Oct 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W J MannH G Tabb
May 2, 1998·Brain Research·T YamasobaJ M Miller
Feb 13, 2001·British Journal of Clinical Pharmacology·L E Schmidt, K Dalhoff
Mar 6, 2003·Brain Research·Yoshimitsu OhinataJochen Schacht
Feb 1, 2006·Ear and Hearing·Donald HendersonBo Hua Hu
Jun 10, 2006·Journal of the American Academy of Audiology·Steven KramerMichael O'Leary
Dec 5, 2006·Hearing Research·Colleen G Le PrellJosef M Miller
Jan 12, 2007·The Annals of Otology, Rhinology, and Laryngology·Thomas SomersErwin Offeciers
Dec 22, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jean-Marc GerardMichel C Gersdorff
Jun 4, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Michele Bauchet St MartinBarry E Hirsch
Mar 13, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·E A Sandilands, D N Bateman
Sep 30, 2009·Biochemical and Biophysical Research Communications·Yu HanJianhua Qiu
Jul 20, 2010·Hearing Research·Cheng-Yu LinYueliang L Guo
Jan 21, 2011·Expert Opinion on Emerging Drugs·Naoki Oishi, Jochen Schacht
Jun 14, 2012·Acta Oto-laryngologica·Karin StrömbäckHelge Rask-Andersen
Sep 1, 2012·International Journal of Audiology·Samuli HannulaElina Mäki-Torkko
Aug 21, 2013·Lancet Neurology·Berthold LangguthDirk De Ridder

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Citations

Dec 6, 2016·Hearing Research·Arwa KurabiAnn C-Y Wong
Jun 19, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Inge WegnerHenricus G X M Thomeer
Jan 18, 2019·International Journal of Audiology·Ulf RosenhallPer Muhr
Sep 5, 2017·Frontiers in Cellular Neuroscience·Volker NoackAllen F Ryan
Jul 17, 2018·BioMed Research International·Min Yong Lee, Yong-Ho Park
Aug 26, 2017·Expert Opinion on Drug Discovery·Daniel Bodmer
Jul 18, 2018·Frontiers in Cellular Neuroscience·Hyun Woo LimArwa Kurabi

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Clinical Trials Mentioned

NCT00525551

Software Mentioned

R Environment for Statistical Computing

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