A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis

The European Respiratory Journal
Anthony De SoyzaRobert Stockley

Abstract

This randomised double-blind placebo-controlled parallel-group multicentre phase IIa study evaluated the effect of the CXCR2 antagonist AZD5069 on sputum neutrophil counts in adults with bronchiectasis.Patients were randomised 1:1 to receive AZD5069 80 mg or placebo orally twice daily for 28 days. Assessments included blood cell counts, inflammatory markers in blood, morning spontaneous sputum, lung function, safety and tolerability and patients completed daily BronkoTest diary cards. The primary outcome measure was the change in absolute sputum neutrophil count.Of 52 randomised patients, 45 completed treatment, 20 (76.9%) out of 26 receiving AZD5069 and 25 (96.2%) out of 26 receiving placebo. AZD5069 reduced the absolute neutrophil cell count in morning sputum by 69% versus placebo (p=0.004); percentage sputum neutrophil count was reduced by 36% (p=0.008). The number of infections/exacerbations was similar with AZD5069 and placebo (nine versus eight), but these led to more study discontinuations with AZD5069 (four versus zero). Sputum interleukin (IL)-6 and growth-regulated oncogene (GRO)-α and serum GRO-α, IL-1ß and IL-8 levels increased with AZD5069 versus placebo (all p<0.001), while serum high-sensitivity C-reactive protei...Continue Reading

References

Feb 1, 1987·Annals of Internal Medicine·N R AnthonisenN A Nelson
Mar 1, 1995·Blood Reviews·M H EllisJ E Groopman
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·C B WilsonR Wilson
Nov 3, 2001·The Journal of Allergy and Clinical Immunology·P G WoodruffJ V Fahy
May 25, 2004·Journal of Leukocyte Biology·Suzanne L TravesLouise E Donnelly
Jul 5, 2005·Thorax·A V KamathE R Chilvers
Mar 25, 2006·American Journal of Respiratory and Critical Care Medicine·Ian M Balfour-LynnUNKNOWN CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators
Dec 21, 2007·The European Respiratory Journal·M UddinR Djukanovic
May 30, 2008·The European Respiratory Journal·J HolmeA L Sullivan
Aug 1, 2009·The European Respiratory Journal·O HolzH Magnussen
Mar 2, 2010·The European Respiratory Journal·Y GernezP Chanez
Jul 22, 2010·Thorax·M C PasteurUNKNOWN British Thoracic Society Bronchiectasis non-CF Guideline Group
Feb 15, 2011·Biochimica Et Biophysica Acta·Shean J Aujla, John F Alcorn
Feb 22, 2011·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Adam T HillDiana Bilton
Dec 24, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R VirtalaL O Cardell
Jan 24, 2012·The European Respiratory Journal·J Stuart ElbornNeil Entwistle
Sep 29, 2012·The European Respiratory Journal·Robert WilsonBarbara Hampel
Dec 18, 2012·Thorax·Anthony De SoyzaUNKNOWN Bronchiectasis Research & Academic Network
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Michael M TunneyJ Stuart Elborn
Feb 26, 2013·Respiratory Medicine·Robert StockleyNoel Snell
Mar 28, 2013·JAMA : the Journal of the American Medical Association·J Stuart Elborn, Michael M Tunney
Nov 5, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gerd DöringMartina Ulrich

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Citations

Dec 19, 2015·The Lancet. Respiratory Medicine·James D Chalmers
Jul 18, 2015·British Journal of Clinical Pharmacology·Stipo JurcevicChristina Keen
Oct 31, 2016·Medical Mycology·Anthony De Soyza, Stefano Aliberti
Dec 13, 2016·Journal of Clinical Medicine·Jun Keng KhooLata Jayaram
May 26, 2017·Expert Review of Respiratory Medicine·Danielle F Wurzel, Anne B Chang
Feb 18, 2017·Current Opinion in Pulmonary Medicine·Hani Abo-Leyah, James D Chalmers
Jun 29, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Simon FinchJames D Chalmers
Mar 2, 2016·Therapeutic Advances in Respiratory Disease·Neil C Thomson
May 29, 2018·Expert Review of Respiratory Medicine·Rodrigo AthanazioMiguel Ángel Martínez-García
Sep 23, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kate H Regan, Adam T Hill
Sep 13, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Scott C BellCatherine A Byrnes
Nov 15, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Justine K NakiwalaDavid M Lowe
Dec 14, 2018·Thorax·Adam T HillMichael R Loebinger
Feb 14, 2018·Journal of Innate Immunity·Dominik HartlCory M Hogaboam
Aug 25, 2018·The European Respiratory Journal·Aili L LazaarRuth Tal-Singer
Oct 2, 2015·The European Respiratory Journal·Miguel Ángel Martínez-GarcíaRosa María Girón Moreno
Feb 18, 2017·Breathe·Margarida RedondoJames D Chalmers
Feb 17, 2018·The European Respiratory Journal·Frauke PedersenHenrik Watz
Mar 16, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Megan L CrichtonJames D Chalmers
Apr 24, 2019·Cancers·Lingyun WuRakesh K Singh
May 10, 2019·F1000Research·Alice E JasperGeorgia M Walton
Dec 23, 2017·Expert Review of Clinical Pharmacology·Andrea S MelaniPaola Rottoli
Jun 10, 2017·Journal of Immunology Research·Carina Kärrman MårdhMatthew Thomas
May 24, 2018·BMC Pulmonary Medicine·Jürgen SchäferDominik Hartl
Jun 13, 2018·American Journal of Respiratory Cell and Molecular Biology·Catherine J ReynoldsRosemary J Boyton
Sep 30, 2019·The European Respiratory Journal·Arietta Spinou, James D Chalmers
Nov 18, 2018·Nature Reviews. Disease Primers·James D ChalmersPamela J McShane
Feb 26, 2019·Frontiers in Immunology·Mohib UddinFrauke Pedersen
Jul 12, 2019·Frontiers in Immunology·Simon SodySven Brandau
Sep 9, 2020·The New England Journal of Medicine·James D ChalmersUNKNOWN WILLOW Investigators
Nov 6, 2020·British Journal of Pharmacology·Farha Naz, Mohd Arish
Feb 6, 2021·Cellular and Molecular Life Sciences : CMLS·Wan-Chi Lin, Michael B Fessler
Mar 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yunfei ZhuHuimin Liu
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Holly R Keir, James D Chalmers
Jul 14, 2021·The Journal of Investigative Dermatology·Shuichiro NakaboMariana J Kaplan
Jan 30, 2021·The European Respiratory Journal·Yan Hui GiamJames D Chalmers

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