A randomised placebo controlled trial of suppressive acyclovir in late pregnancy in women with recurrent genital herpes infection

British Journal of Obstetrics and Gynaecology
P BrocklehurstA Mindel

Abstract

To evaluate the efficacy and safety of a suppressive course of acyclovir in late pregnancy in women with recurrent genital herpes infection on the incidence of viral shedding, herpes lesion development and caesarean section for recurrent genital herpes. Double-blind, randomised placebo controlled clinical trial. A department of genitourinary medicine in Sheffield and an antenatal clinic in London. Pregnant women with recurrent genital herpes infection at < 36 weeks of gestation. Participating women were given acyclovir 200 mg four times a day (or matching placebo) from 36 weeks of gestation until the time of delivery. Women were seen weekly and viral cultures were obtained from the cervix and vulva. Decisions regarding mode of delivery were left to the discretion of the attending obstetrician. Delivery by caesarean section for recurrent genital herpes infection. Number of episodes of recurrent genital herpes infection and number of episodes of asymptomatic viral shedding during the treatment period. In addition blood was taken at two weekly intervals to determine acyclovir levels. The total number of women recruited was 63 (31 received acyclovir and 32 received placebo). The number of women undergoing delivery by caesarean sect...Continue Reading

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