A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy

The British Journal of Nutrition
Tsz Hong LawHolger A Volk

Abstract

Despite appropriate antiepileptic drug treatment, approximately one-third of humans and dogs with epilepsy continue experiencing seizures, emphasising the importance for new treatment strategies to improve the quality of life of people or dogs with epilepsy. A 6-month prospective, randomised, double-blinded, placebo-controlled cross-over dietary trial was designed to compare a ketogenic medium-chain TAG diet (MCTD) with a standardised placebo diet in chronically antiepileptic drug-treated dogs with idiopathic epilepsy. Dogs were fed either MCTD or placebo diet for 3 months followed by a subsequent respective switch of diet for a further 3 months. Seizure frequency, clinical and laboratory data were collected and evaluated for twenty-one dogs completing the study. Seizure frequency was significantly lower when dogs were fed the MCTD (2·31/month, 0-9·89/month) in comparison with the placebo diet (2·67/month, 0·33-22·92/month, P=0·020); three dogs achieved seizure freedom, seven additional dogs had ≥50 % reduction in seizure frequency, five had an overall <50 % reduction in seizures (38·87 %, 35·68-43·27 %) and six showed no response. Seizure day frequency were also significantly lower when dogs were fed the MCTD (1·63/month, 0-7·...Continue Reading

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Citations

Jan 17, 2016·Epilepsy & Behavior : E&B·Rowena M A PackerHolger A Volk
Feb 24, 2016·Journal of Veterinary Internal Medicine·M PodellS R Platt
May 6, 2016·Frontiers in Veterinary Science·Tina KochAndrea Fischer
Apr 17, 2016·The Veterinary Record·Holger A Volk
Feb 18, 2016·The British Journal of Nutrition·Tsz Hong LawHolger A Volk
Nov 16, 2019·Journal of the American Veterinary Medical Association·Kimberly A May, Dorothy P Laflamme
Apr 16, 2020·Journal of Veterinary Internal Medicine·Benjamin A BerkHolger A Volk
Jul 31, 2020·The Veterinary Record·Koen Maurits SantifortPaul Mandigers
Oct 6, 2018·Nature Reviews. Neurology·Orrin DevinskyBarbara Natterson-Horowitz
Mar 15, 2019·Epilepsia Open·Susan A MasinoBeth Zupec-Kania
Jan 9, 2021·Frontiers in Veterinary Science·Rachel PillaHolger Andreas Volk
Dec 4, 2020·Epilepsy & Behavior : E&B·Benjamin Andreas BerkHolger Andreas Volk
Mar 4, 2021·The Veterinary Clinics of North America. Small Animal Practice·Rachel Pilla, Jan S Suchodolski
Mar 29, 2021·The Veterinary Clinics of North America. Small Animal Practice·Valarie V Tynes, Gary M Landsberg
May 8, 2021·Journal of Veterinary Internal Medicine·Gareth Michael Couper JonesRowena Mary Anne Packer

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Methods Mentioned

BETA
sedation

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