PMID: 9165135Apr 1, 1997Paper

A randomised trial of accelerated versus conventional radiotherapy in head and neck cancer

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
S M JacksonJ S Durham

Abstract

To study the effect of accelerated radiation treatment in locally advanced head and neck cancer, a prospective randomised trial was conducted comparing two fractionation schemes which differed only in the overall treatment time; fraction size and total dose were the same in both arms. Eighty-two patients with stage 3 or 4 squamous cell cancer of the oral cavity, oropharynx, hypopharynx or larynx considered suitable for radical radiotherapy as primary treatment were stratified by site and stage and randomised to receive 66 Gy in 33 2 Gy daily fractions in 45-48 days (o.d.) or 66 Gy in 33 2 Gy twice daily fractions in 22-25 days (b.i.d.). An initial improved clinical response in tumour control in the b.i.d. arm was not sustained and the 3 year recurrence free survival and overall survival rates were similar and not significantly different. The actuarial recurrence free survival was 49.1% in the b.i.d. arm and 44.3% in the o.d. arm. The disease free 3 year survival was 59.4% and 56.8%, respectively. The acute and late normal tissue effects were scored using the RTOG scale. As expected the acute effects were much greater in the b.i.d. arm. The combined grade 3 and 4 late effects were similar but the proportion of grade 4 reactions ...Continue Reading

References

Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J C HoriotM Bolla
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J F Fowler, M J Lindstrom
Mar 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M B BartonE Maki
Jan 11, 1991·International Journal of Radiation Oncology, Biology, Physics·T F PajakL W Davis
Jun 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D S LambM J Dally
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J C HoriotM Bolla
Mar 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P OlmiC Fallai
Aug 1, 1989·The British Journal of Radiology·J F Fowler
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·B MaciejewskiA Hliniak
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
May 1, 1974·Cancer·J P BatainiN A Ghossein
May 1, 1973·The British Journal of Radiology·J Denekamp
Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·H R WithersN Gupta
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·J BourhisE Malaise
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·C C Wang
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·K H PigottM I Saunders

❮ Previous
Next ❯

Citations

Mar 5, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·R MiralbellB Pastoors
Nov 15, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Bena CartmillSandro Porceddu
Dec 21, 2000·Current Oncology Reports·K S Hu, L B Harrison
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Stefanie PabstWolfgang Dörr
Mar 19, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Abderrahim ZouhairMahmut Ozsahin
Apr 9, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jesper G EriksenUNKNOWN Danish Head and Neck Cancer study group (DAHANCA)
Oct 31, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Dobrowsky, J Naudé
Apr 28, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M JacksonA D Flores
Jul 6, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M G PoulsenQ Walker
Dec 4, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Dörr, J H Hendry
Feb 7, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A HliniakE Gradoń
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jack F FowlerJosé H Leborgne
Jul 7, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H KaandersK K Ang
Aug 6, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M Stuschke, H D Thames
Jan 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J P WylieN J Slevin
Mar 4, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J CorryL J Peters
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Anne W M LeeJohn F Fowler
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Yee-Min JenPei-Wei Shueng
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Wolfgang DörrCatherine L Farrell
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·R MacKenzieE Franssen
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A Trotti
Feb 14, 2002·Critical Reviews in Oncology/hematology·Lisa LicitraJean-Louis Lefebvre
Nov 9, 2002·The Lancet Oncology·Linh N Nguyen, K Kian Ang
Jan 5, 2002·The New England Journal of Medicine·A ForastiereD Sidransky
Jun 7, 2000·Current Opinion in Oncology·W M MendenhallJ T Parsons
Apr 8, 2004·Current Opinion in Oncology·Jean BourhisJean Pierre Pignon
Jul 1, 2010·Indian Journal of Cancer·S A BhideC M Nutting
May 5, 2012·The British Journal of Radiology·S A BhideC M Nutting
Dec 9, 1998·Cancer Investigation·W M Mendenhall, J T Parsons
Feb 22, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nina Munk LyhneJens Overgaard
Jan 23, 2016·Lasers in Medical Science·Margherita GobboMatteo Biasotto
Sep 10, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shreerang A BhideChristopher M Nutting
Apr 23, 2010·Oral Oncology·S A Bhide, C M Nutting
Jan 25, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jolie RingashJohn Waldron
Oct 9, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bernard CummingsBrian O'Sullivan
Mar 14, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jamie A DeanChristopher M Nutting
Mar 9, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jamel DaoudMounir Frikha
Aug 11, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nina M LyhneJens Overgaard
Nov 7, 2009·Head & Neck·William M MendenhallJohn W Werning

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2021 Meta ULC. All rights reserved