A randomised trial of hypertonic saline during hospitalisation for exacerbation of cystic fibrosis

Thorax
Ruth L DenticePeter T P Bye

Abstract

The mucoactive effects of hypertonic saline should promote exacerbation resolution in people with cystic fibrosis (CF). To determine the effects of hypertonic saline inhalation during hospitalisation for exacerbation of CF on length of stay, lung function, symptoms, oxygenation, exercise tolerance, quality of life, bacterial load and time to next hospitalisation. 132 adults with an exacerbation of CF were randomised to inhale three nebulised doses a day of either 4 mL 7% saline or a taste-masked control of 0.12% saline, throughout the hospital admission. The primary outcome measure was length of hospital stay. All participants tolerated their allocated saline solution. There was no significant difference in length of stay, which was 12 days in the hypertonic saline group and 13 days in controls, with a mean between-group difference (MD) of 1 day (95% CI 0 to 2). The likelihood of regaining pre-exacerbation FEV1 by discharge was significantly higher in the hypertonic saline group (75% vs 57%), and the number needed to treat was 6 (95% CI 3 to 65). On a 0-100 scale, the hypertonic saline group had significantly greater reduction in symptom severity than the control group at discharge in sleep (MD=13, 95% CI 4 to 23), congestion (...Continue Reading

References

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Citations

Jan 16, 2016·Thorax·Sonya L Heltshe, Christopher H Goss
Jun 14, 2017·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Feb 2, 2017·The Cochrane Database of Systematic Reviews·Mark Elkins, Ruth Dentice
Jul 7, 2018·Pediatric Pulmonology·Michael S Schechter
Sep 28, 2018·The Cochrane Database of Systematic Reviews·Peter Wark, Vanessa M McDonald
Aug 21, 2018·Current Opinion in Pulmonary Medicine·Sylvia Szentpetery, Patrick A Flume
Feb 29, 2020·The Cochrane Database of Systematic Reviews·Mark Elkins, Ruth Dentice
Aug 7, 2017·Expert Review of Respiratory Medicine·Michael F PapacostasSusan Hupp
Jul 19, 2016·Clinical Medicine Insights. Pediatrics·Corinne A MuirheadKelvin D MacDonald
Apr 25, 2017·Journal of Parkinson's Disease·Laurie K MischleyJeannie M Padowski
Apr 16, 2019·Frontiers in Pharmacology·Andre SchultzTom Snelling
Jul 27, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Rodrigo Abensur AthanazioUNKNOWN Grupo de Trabalho das Diretrizes Brasileiras de Diagnóstico e Tratamento da Fibrose Cística.
Nov 17, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Charlie McLeodThomas L Snelling
Dec 5, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Yin ZhangJilei Lin
Aug 8, 2021·Italian Journal of Pediatrics·Vito TerlizziDiletta Innocenti
Jul 30, 2021·International Journal of Clinical Practice·Renata Maba Gonçalves WamosyCamila Isabel Santos Schivinski
Sep 10, 2021·Pediatric Pulmonology·Alejandro TeperFacundo García Bournissen

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