A randomised trial of low dose aspirin for primiparae in pregnancy. The Jamaica Low Dose Aspirin Study Group

British Journal of Obstetrics and Gynaecology
J Golding

Abstract

To investigate whether low dose aspirin medication given to primiparous women provides benefit in preventing pre-eclampsia or intrauterine growth retardation. Randomised double-blind controlled trial of low dose aspirin and placebo in pregnancy. Residents of the parishes of Kingston and St Andrew, Jamaica; 6275 primiparae enrolled between 12 and 32 weeks of gestation. Hypertensive disorders of pregnancy (including pre-eclampsia and eclampsia), preterm delivery, and low birthweight. In addition, to assess whether enrollment early, rather than late had more beneficial effect. Possible adverse effects on the woman and her infant were monitored. Of enrolled primiparae, 97% were followed throughout pregnancy. There were no differences between those on aspirin and those on placebo in the development of hypertensive disorders (e.g. for a rise in diastolic pressure of 25 mmHg the odds ratio [OR] was 1.02 [95% CI 0.86-1.21]; for proteinuric pre-eclampsia OR 1.15 [95% CI 0.92-1.44]; eclampsia OR 0.82 [95% CI 0.44-1.53]); except for oedema which was significantly less prevalent in those on aspirin (OR 0.85 [95% CI 0.75-0.96]). Women on aspirin were no significantly less likely to deliver preterm (OR 0.93 [95% CI 0.79-1.09]) or have a larg...Continue Reading

References

May 1, 1991·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J W KeelingJ Golding
Aug 1, 1991·Acta paediatrica Scandinavica·K CoardJ Golding
Apr 1, 1994·Paediatric and Perinatal Epidemiology·C EscofferyJ Golding
Apr 1, 1994·Paediatric and Perinatal Epidemiology·R GreenwoodD Ashley
Apr 1, 1994·Paediatric and Perinatal Epidemiology·R GreenwoodJ Golding

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Hypertension Reports·R ShearJ M Moutquin
Aug 5, 2003·Current Treatment Options in Neurology·Michael A. Sloan, Barney J. Stern
Nov 30, 2000·Obstetrics and Gynecology·R L FerrerJ Cornell
Jan 3, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H C Wallenburg
Apr 25, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S Uzan
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·D O Anumba, S C Robson
Aug 19, 1999·Clinical Obstetrics and Gynecology·E R NorwitzJ T Repke
Mar 20, 1999·BMJ : British Medical Journal·L Duley
Apr 29, 2011·BMC Public Health·Mehnaz JabeenZulfiqar A Bhutta
Jun 2, 2005·Journal of Experimental & Clinical Assisted Reproduction·Bradley S HurstMichelle L Matthews
Jun 10, 2011·Journal of Postgraduate Medicine·N A Trivedi
May 20, 2014·Seminars in Perinatology·Alexander M Friedman, Kirsten L Cleary
Mar 27, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·P DeruelleD Subtil
Feb 18, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E K KahwaR Wilks
May 22, 2007·Lancet·Lisa M AskieUNKNOWN PARIS Collaborative Group
Nov 19, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A M McCaw-BinnsJ Golding
Apr 8, 2015·Paediatric and Perinatal Epidemiology·K S JosephAnick Bérard
Sep 26, 2012·Chronobiology International·Diana E AyalaRamón C Hermida
Feb 20, 2013·American Journal of Obstetrics and Gynecology·Bart Jan VoskampEva Pajkrt
Nov 26, 2008·American Journal of Obstetrics and Gynecology·Christina M ScifresGeorge A Macones
Aug 19, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akihide OhkuchiShigeki Matsubara
Jan 13, 2017·Obstetrics and Gynecology·Elvira O G van VlietMartijn A Oudijk
May 14, 2010·Pharmaceuticals·Chun Shing Kwok, Yoon K Loke
May 14, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Damien SubtilUNKNOWN Essai Régional Aspirine Mère-Enfant (ERASME) Collaborative Group
Feb 14, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F ParkJ Hyett
Jan 31, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S RobergeE Bujold
Mar 8, 2003·Hypertension·Ramón C HermidaManuel Iglesias
Jul 20, 2007·The Cochrane Database of Systematic Reviews·M KnightJ F King
Apr 20, 2007·The Cochrane Database of Systematic Reviews·L DuleyJ F King
Apr 3, 2015·The Journal of Clinical Hypertension·Ting-ting XuXiao-dong Wang
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Lelia DuleyLisa M Askie
Sep 4, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M TurnerS Kumar
Apr 24, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S Meher, Z Alfirevic
Jul 6, 2000·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·N MakkonenP Kirkinen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.