A randomised trial of mode of delivery in women infected with the human immunodeficiency virus

British Journal of Obstetrics and Gynaecology
M L NewellG Pardi

Abstract

During the pilot phase of a trial to evaluate the effectiveness of caesarean section delivery compared with vaginal delivery in reducing mother-to-child transmission of human immunodeficiency virus (HIV) infection, the feasibility of randomisation to mode of delivery was assessed. At 36 weeks of pregnancy, women infected with HIV were randomly allocated to either caesarean section delivery at 38 weeks or vaginal delivery. Information was also collected on the reasons why women were not enrolled, either because they refused or had a contraindication. Fifty-one centres in six European countries. Pregnant women with confirmed HIV-1 infection. Randomisation. Three-hundred and thirty-nine women had been randomised by the end of 1996, the large majority from Italy (n = 250) and France (n = 54), with 22 from South Africa, three from Sweden, nine from Barcelona and one from London. A further 150 women were eligible but had not been randomised. Forty-eight women (14%) were not delivered according to the arm to which they were randomised; the majority (n = 44) were changed from vaginal to caesarean section delivery. There is wide variation between European countries in the acceptability and adherence to the mode of delivery trial. The pi...Continue Reading

References

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Aug 15, 1983·American Journal of Obstetrics and Gynecology·T F Nielsen, K H Hökegård
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Citations

Jun 4, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nelly BriandUNKNOWN ANRS-EPF CO1-CO11 Study Group
Jan 18, 2008·HIV Medicine·I Grosch-WoernerUNKNOWN Multicenter Interdisciplinary Study Group Germany/Austria
Jun 28, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S FioreG Pardi
Apr 1, 1999·The New England Journal of Medicine·UNKNOWN International Perinatal HIV GroupR Tuomala
Mar 1, 2002·The Cochrane Database of Systematic Reviews·P Brocklehurst
Sep 30, 1999·Journal of Perinatal Medicine·P GrecoL Selvaggi

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