PMID: 11332540May 3, 2001Paper

A randomization test-based method for risk assessment in neurotoxicology

Risk Analysis : an Official Publication of the Society for Risk Analysis
M A BogdanJ R Glowa

Abstract

A current trend in risk assessment for systemic toxicity (noncancer) endpoints is to utilize the observable range of the dose-effect curve in order to estimate the likelihood of obtaining effects at lower concentrations. Methods to accomplish this endeavor are typically based on variability in either the effects of fixed doses (benchmark approaches), or on variability in the doses producing a fixed effect (probabilistic or tolerance-distribution approaches). The latter method may be particularly desirable because it can be used to determine variability in the effect of an agent in a population, which is an important goal of risk assessment. This method of analysis, however, has typically been accomplished using dose-effect data from individual subjects, which can be impractical in toxicology. A new method is therefore presented that can use traditional groups-design data to generate a set of dose-effect functions. Population tolerances for a specific effect can then be estimated from these model dose-effect functions. It is based on the randomization test, which assesses the generality of a data set by comparing it to a data set constructed from randomized combinations of single point estimates. The present article describes an...Continue Reading

Citations

Apr 15, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·R W West, R L Kodell
Oct 24, 2008·Environmental Health : a Global Access Science Source·Marina Bjørling-PoulsenPhilippe Grandjean

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