A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats

Veterinary Anaesthesia and Analgesia
Luiz Cesar P SantosPati Kirch

Abstract

To determine the effect of ondansetron on the incidence of vomiting in cats pre-medicated with dexmedetomidine and buprenorphine. Randomized, blinded, controlled trial. Eighty-nine female domestic shorthair cats, aged 3-60 months (median, 12 months) and weighing 1.2-5.1 kg. Each cat received dexmedetomidine (40 μg kg(-1)) plus buprenorphine (20 μg kg(-1)), intramuscularly as pre-anesthetic medication. Cats were assigned to three treatment groups: ondansetron (0.22 mg kg(-1), intramuscular [IM]), either 30 minutes before the pre-anesthetic medication (ONDA group, n = 31) or with the pre-anesthetic medication (OPM group, n = 30) mixed with the pre-anesthetic medications in the same syringe, or not to receive the antiemetic (control group, n = 28). Emesis was recorded as an all-or-none response. The number of episodes of emesis and the time until onset of the first emetic episode were recorded for each cat. Clinical signs of nausea were recorded whenever they occurred, and a numerical rating scale was used to quantify these signs. Data were analyzed using Kruskal-Wallis and Chi-square test; a Bonferroni correction was made for six comparisons; thus, the two-sided p for significance was 0.05/6 = 0.008. There was a significant reduc...Continue Reading

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Citations

Dec 8, 2015·Journal of the American Veterinary Medical Association·Vincent J Thawley, Kenneth J Drobatz
Dec 18, 2013·Journal of Veterinary Pharmacology and Therapeutics·J M QuimbyD L Gustafson
Apr 1, 2016·Journal of the American Veterinary Medical Association·Jennifer L WilleyMonica C Clare
May 14, 2016·Journal of the American Veterinary Medical Association·Manuel Martin-FloresRobin D Gleed
Nov 5, 2015·Journal of Feline Medicine and Surgery·Manuel Martin-FloresRobin D Gleed
Feb 14, 2013·Journal of Feline Medicine and Surgery·Daniel J BatchelorAlexander J German
Jan 24, 2017·Journal of Feline Medicine and Surgery·Lara B ZajicJessica M Quimby
Aug 31, 2017·Journal of Veterinary Emergency and Critical Care·Margaret ThiesVirginia Sinnott
Jul 11, 2018·Journal of Feline Medicine and Surgery·Sheilah A RobertsonGregg M Griffenhagen
Jun 27, 2019·Journal of Veterinary Emergency and Critical Care·Michael R NystromChika C Okafor
Jan 16, 2021·Animals : an Open Access Journal From MDPI·Stefanie RiemerNadja Affenzeller
May 18, 2021·Journal of Equine Veterinary Science·Alshimaa M M Farag, Hussam M M Ibrahim

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