A randomized, blinded, placebo-controlled trial of education and iron supplementation for mitigation of iron deficiency in regular blood donors

Transfusion
Alan E MastBryan R Spencer

Abstract

The historical approach of offering dietary advice to donors with low hemoglobin (Hb) is ineffective for preventing iron deficiency in frequent donors. Alternative approaches to maintaining donor iron status were explored. Frequent blood donors were randomly assigned into five arms for 2 years of follow-up. Three double-blinded arms provided 60 once-daily pills after each donation (38, 19, or 0 mg of iron). Two single-blinded arms provided iron status (ferritin) or no information letters after each donation. Ferritin, soluble transferrin receptor, and complete blood count were measured at each donation. There were 692 subjects enrolled and 393 completed the study. Subjects in pill groups deenrolled more than those in letter groups (39% vs. 7%). Adverse events occurred equally in subjects receiving iron or placebo pills. Of those completing the study, the prevalence of ferritin of less than 12 or less than 26 ng/mL declined by more than 50% and was statistically indistinguishable in the three intervention groups (19 or 38 mg of iron; iron status letter). Longitudinal analyses of all subjects showed improved iron status in iron pill groups and worsening iron status in control groups (placebo; no information letter). The iron pill...Continue Reading

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References

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Citations

May 28, 2016·Transfusion·Ritchard G CableUNKNOWN National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)
Jun 15, 2016·Transfusion·Sheila F O'Brien
Jun 15, 2016·Transfusion·Anne F Eder
Jun 17, 2016·Transfusion·Mindy GoldmanSheila F O'Brien
May 17, 2018·British Journal of Haematology·Joseph E Kiss, Ralph R Vassallo
Sep 28, 2018·Transfusion·Mindy GoldmanSheila F O'Brien
Nov 27, 2018·Transfusion·Tamir KaniasUNKNOWN NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III Program
Dec 13, 2016·Transfusion·Mindy GoldmanSheila F O'Brien
Feb 7, 2017·Transfusion·Melanie C ChanskyAlan E Mast
Jun 21, 2019·Transfusion·Ritchard G Cable, Bryan R Spencer
Sep 26, 2020·Transfusion·Bryan R SpencerAlan E Mast
Sep 7, 2018·Military Medicine·Andrew P CapJennifer Gurney
Dec 10, 2020·Transfusion·Ralph R Vassallo
Dec 29, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Patrick AduDavid Larbi Simpong

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