A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation

Scientific Reports
Yuji MikoshibaHiroko Terasaki

Abstract

We prospectively investigated the changes in choroidal blood flow and morphology after panretinal photocoagulation (PRP) in 39 eyes with severe nonproliferative diabetic retinopathy (S-NPDR). Seventeen eyes underwent PRP by conventional laser and 22 eyes underwent pattern scan laser (PASCAL). The choroidal blood flow was assessed by laser speckle flowgraphy, and the subfoveal choroidal thickness (SFCT) was measured with optical coherence tomography before and 1, 4, 8, and 12 weeks after the two types of PRP treatments. The choroidal mean blur rate (MBR) at the macular region was significantly reduced to 86.4% of the baseline level in the conventional laser group and 85.7% in the PASCAL group at Week 12 (P = 0.001, P < 0.001, respectively). The SFCT was significantly increased at 1 week following PRP but it was significantly reduced at Week 8 (P = 0.001, P < 0.001, respectively) in both groups. The differences in the ratio of the MBR and the SFCT was not significant between the conventional laser and PASCAL groups at any time after PRP. The results suggest that appropriate PRP treatments even by the PASCAL method will reduce the choroidal blood flow and the choroidal morphological components.

References

May 1, 1994·The British Journal of Ophthalmology·N FujioJ W McMeel
Mar 5, 1998·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·R AugstenJ Strobel
Apr 4, 1998·Acta Ophthalmologica Scandinavica·J R MacKinnonD Cameron
Feb 14, 2003·Archives of Ophthalmology·Hiroaki IsonoHitoshi Fujii
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Howard I SavageCharles P Wilkinson
Mar 2, 2006·Retina·Mark S BlumenkranzDaniel Palanker
Jan 16, 2008·Archives of Ophthalmology·Atul JainDaniel Palanker
Sep 4, 2009·Acta Ophthalmologica·Tetsuya SugiyamaSelim Orgul
Aug 13, 2010·Investigative Ophthalmology & Visual Science·Miyuki NagaharaMakoto Araie
Feb 25, 2011·Investigative Ophthalmology & Visual Science·Christine J LeeRobert A Linsenmeier
Sep 23, 2011·American Journal of Ophthalmology·Aimee V ChappelowPeter K Kaiser
Oct 21, 2011·The New England Journal of Medicine·Neil M BresslerFrederick L Ferris
Mar 20, 2012·Investigative Ophthalmology & Visual Science·Shinichi UsuiTomohiro Iida
Sep 4, 2012·American Journal of Ophthalmology·Masayo KimuraKazuhisa Sugiyama
Mar 20, 2015·Investigative Ophthalmology & Visual Science·Zhengwei ZhangQing Zhang

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