A randomized clinical trial of immunization with combined hepatitis A and B versus hepatitis B alone for hepatitis B seroprotection in hemodialysis patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Jennifer TungChristine H Lee

Abstract

The Centers for Disease Control and Prevention recommend immunizing susceptible high-risk groups, such as hemodialysis patients, against hepatitis B virus. However, hemodialysis patients may not develop seroprotective antibodies despite receiving high doses of the vaccine. Recent reports indicate that combined vaccination against hepatitis B and hepatitis A viruses may improve the immunogenicity of hepatitis B vaccine in healthy individuals, but the effectiveness of this strategy in hemodialysis patients is unknown. Prospective randomized controlled trial. Hepatitis B virus-seronegative hemodialysis patients with undetectable antibody levels at baseline. Intramuscular administration of Twinrix (inactivated hepatitis A virus [720 ELISA units] and purified hepatitis B virus surface antigen [20 μg]; GlaxoSmithKline) and Engerix-B (purified hepatitis B virus surface antigen [20 μg]) at 0, 1, and 6 months plus Engerix-B, 40 μg, at month 2 (intervention arm) or Engerix-B, 40 μg, at 0, 1, 2, and 6 months (control arm). Both groups received a total dose of 160 μg of hepatitis B antigen. The primary outcome was the difference in seroprotection rates at 7 months, defined by antibody titers >10 mIU/mL. The secondary outcome was frequency ...Continue Reading

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Citations

Oct 3, 2012·ISRN Gastroenterology·Mohammad Hossein Somi, Babak Hajipour
Jun 12, 2013·Seminars in Dialysis·Ritu SoniMark Unruh
Apr 29, 2015·Human Vaccines & Immunotherapeutics·Alicja E Grzegorzewska
Aug 28, 2014·Journal of Gastroenterology and Hepatology·Yolima Cossio-GilFrancesc Casellas-Jordà
Jun 25, 2016·Annals of Hematology·Andrew J UllmannUNKNOWN Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology (AGIHO/DGHO) and the DAG-KBT (Ge
Apr 25, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C T RiegerUNKNOWN German Society of Hematology and Medical Oncology Infectious Diseases Working Group (AGIHO)
Jan 11, 2014·Expert Review of Vaccines·Roy MathewJeffrey S Kennedy
Jan 30, 2016·The International Journal of Artificial Organs·Fabrizio FabriziPiergiorgio Messa
Jan 12, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Fabrizio FabriziEzequiel Ridruejo
Jun 26, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Fabrizio FabriziEzequiel Ridruejo

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