A randomized clinical trial of prophylactic OKT3 monoclonal antibody in liver allograft recipients

Archives of Surgery
A B CosimiA P Monaco

Abstract

Seventy-nine hepatic allograft recipients were randomized to receive either conventional immunosuppression, including cyclosporine, azathioprine, and steroids (41 patients), or investigational therapy in which OKT3 replaced cyclosporine during the first postoperative week (38 patients). Early rejection occurred in 29 patients (71%) in the conventional group and 15 patients (39%) in the OKT3 group. Posttransplantation renal dysfunction occurred in 12 patients (29%) in the conventional group and 6 patients (16%) in the OKT3 group. Mean initial hospital stay was 34.1 +/- 18.8 days in the conventional group compared with 29.1 +/- 16.8 days in the OKT3 group. Cumulative patient survival (mean follow-up, 17.8 +/- 7.1 months) was 73.2% (30/41) for the conventional group and 84.2% (32/38) for the OKT3 group. Prophylactic OKT3 is indicated especially for liver allograft recipients with other complicating conditions that make management of early rejection unusually difficult.

Citations

Oct 1, 1991·Digestive Diseases and Sciences·J Fung, T Starzl
Jul 12, 2008·British Journal of Anaesthesia·R G Craig, J M Hunter
Jul 1, 1992·Journal of Medical Virology·S SutherlandR Williams
Aug 7, 2012·Transplantation Reviews·Lionel RostaingOlivier Boillot
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David J PostDavid C Mulligan
Sep 11, 2010·Current Opinion in Immunology·Adrian R Kendal, Herman Waldmann
May 1, 1991·American Journal of Surgery·C W PinsonR S Johnson
Jun 1, 1994·The Annals of Thoracic Surgery·C G McGregorJ C McDougall
Jul 19, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gerit NiemeyerBjoern Nashan
Jun 6, 2014·The Cochrane Database of Systematic Reviews·Luit PenningaChristian Gluud
Apr 1, 2017·The Cochrane Database of Systematic Reviews·Manuel Rodríguez-PerálvarezKurinchi Selvan Gurusamy
Jun 1, 2014·The Cochrane Database of Systematic Reviews·Luit PenningaChristian Gluud
May 16, 1991·The New England Journal of Medicine

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