A randomized clinical trial to assess the effect of statins on skeletal muscle function and performance: rationale and study design.

Preventive Cardiology
Paul D ThompsonEric P Hoffman

Abstract

Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins are the most effective medications for reducing elevated concentrations of low-density lipoprotein cholesterol (LDL-C). Statins reduce cardiac events in patients with coronary artery disease and previously healthy persons. Current recommendations for LDL-C treatment goals indicate that more patients will be treated with higher doses of these medications. Statins have been extremely well-tolerated in controlled clinical trials but are increasingly recognized to produce skeletal muscle myalgia, cramps, and weakness. The reported frequency of such mild symptoms is not clear, and muscle performance has not been examined with these medications. Accordingly, the present investigation, the Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study, will recruit approximately 440 healthy persons. Participants will be randomly assigned to treatment with atorvastatin 80 mg/d or placebo. Handgrip, elbow and knee isometric and isokinetic strength, knee extensor endurance, and maximal aerobic exercise performance will be determined at baseline. Participants will undergo repeat testing after 6 months of treatment or after meeting the study definition of statin ...Continue Reading

References

Sep 1, 1978·American Journal of Epidemiology·R S PaffenbargerR T Hyde
Aug 1, 1987·Pain·Ronald Melzack
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M UcarR Dahlqvist
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Feb 15, 2002·The New England Journal of Medicine·Judy A StaffaLanh Green
Jul 20, 2002·Journal of Cardiovascular Pharmacology·Helmut SinzingerBernhard A Peskar
Jul 27, 2002·Journal of the American College of Cardiology·Richard C PasternakUNKNOWN National Heart, Lung and Blood Institute
Aug 21, 2002·Circulation·Richard C PasternakUNKNOWN National Heart, Lung and Blood Institute
Oct 2, 2002·Annals of Internal Medicine·Paul S PhillipsUNKNOWN Scripps Mercy Clinical Research Center
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Paul D ThompsonRichard H Karas
Mar 10, 2004·The American Journal of Medicine·Robert S Rosenson
Mar 26, 2004·The Journal of Pain : Official Journal of the American Pain Society·Gabriel TanBilal F Shanti
Sep 11, 2004·Journal of the American College of Cardiology·Scott M GrundyUNKNOWN Coordinating Committee of the National Cholesterol Education Program
Feb 19, 2005·Journal of Applied Physiology·Andreas KatsiarasBret H Goodpaster
Mar 10, 2005·The New England Journal of Medicine·John C LaRosaUNKNOWN Treating to New Targets (TNT) Investigators
Aug 12, 2005·Neurorehabilitation and Neural Repair·Bruce H Dobkin
Oct 15, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Maria L UrsoPaul D Thompson
Jan 26, 2006·Basic & Clinical Pharmacology & Toxicology·Kari SoininenKari T Kivistö
Mar 8, 2007·Journal of the American Geriatrics Society·Joseph V AgostiniJohn Concato
Apr 6, 2007·Journal of Inherited Metabolic Disease·N M FisherG D Vladutiu
Jun 1, 2007·European Journal of Clinical Investigation·M GuazziM D Guazzi
Oct 24, 2007·The American Journal of Cardiology·Joanna M YoungRussell S Scott
Feb 5, 2008·Current Opinion in Pharmacology·Pascal SirventAlain Lacampagne
Jul 25, 2008·The New England Journal of Medicine·UNKNOWN SEARCH Collaborative GroupR Collins
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group

❮ Previous
Next ❯

Citations

Dec 15, 2010·European Journal of Applied Physiology·Beth ParkerPaul Thompson
Jul 4, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D RosenbaumE Bruckert
Sep 25, 2012·Exercise and Sport Sciences Reviews·Beth A Parker, Paul D Thompson
Aug 17, 2012·Medicine and Science in Sports and Exercise·Adam S GrimaldiPaul D Thompson
Jul 12, 2014·Sports Medicine·Zsolt Murlasits, Zsolt Radák
May 6, 2014·Journal of Clinical Lipidology·Robert S Rosenson The National Lipid Association's Muscle Safety Expert Panel
Jun 4, 2013·Journal of Clinical Lipidology·Beth A ParkerPaul D Thompson
Aug 10, 2011·Clinics in Geriatric Medicine·Yves RollandBruno Vellas
Jun 16, 2015·Journal of Clinical Lipidology·Gregory A PanzaPaul D Thompson
Nov 28, 2012·Journal of the American Geriatrics Society·Shelly L GrayAndrea Z LaCroix
Feb 26, 2011·The American Journal of Cardiology·Afrooz ArdestaniPaul D Thompson
Dec 30, 2014·Atherosclerosis·Beth A TaylorPaul D Thompson
Oct 25, 2011·Atherosclerosis·Beth A ParkerPaul D Thompson
Nov 28, 2012·Circulation·Beth A ParkerPaul D Thompson
Aug 31, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Amanda ZaleskiLinda S Pescatello
Jan 1, 2014·International Scholarly Research Notices·Kevin D BallardPaul D Thompson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.