PMID: 7020917Jun 15, 1981Paper

A randomized comparative trial of chemotherapy and irradiation therapy for stage II breast cancer

Cancer
M R CooperC L Spurr

Abstract

One hundred fifty-eight evaluable patients with Stage II carcinoma of the breast with positive lymph nodes were treated either with adjuvant chemotherapy or irradiation therapy followed by chemotherapy. Patients were randomized to test the effectiveness of L-phenylalanine mustard (L-PAM) with and without postoperative irradiation therapy (R.T.) against cyclophosphamide, 5-fluorouracil, and methotrexate (CMF) with and without postoperative irradiation therapy in decreasing the frequency of recurrence. No significant difference was observed between L-PAM as compared with R.T. plus L-PAM (P = 0.85). The difference between CMF and R.T. plus CMF was significant in support of CMF alone (P = 0.04). The frequency of recurrence between R.T. plus L-PAM and R.T. plus CMF showed no difference. A comparison of the chemotherapy only regimens showed an advantage of CMF over L-PAM (P = 0.05). Both the delay in starting chemotherapy and the significant decrease in percent optimal drug dosage during the first six cycles of therapy are factors that may influence the high frequency of relapse observed in the R.T. plus chemotherapy groups. Of the four treatments, CMF has the lowest frequency of recurrence.

References

Jul 1, 1978·Lancet·A R TurnbullJ D Fraser
Sep 1, 1979·Cancer·R G CooperO Glidewell
Nov 1, 1977·International Journal of Radiation Oncology, Biology, Physics·H Høst, I O Brennhovd
Nov 1, 1977·International Journal of Radiation Oncology, Biology, Physics·A Wallgren
Jun 1, 1976·Cancer·R R WeichselbaumS Hellman
Jan 16, 1975·The New England Journal of Medicine·B FisherE R Fisher
Feb 19, 1976·The New England Journal of Medicine·G BonadonnaU Veronesi
Jan 3, 1980·The New England Journal of Medicine·I C Henderson, G P Canellos
Jul 18, 1980·JAMA : the Journal of the American Medical Association·J A CapriniE F Scanlon
Jan 10, 1980·The New England Journal of Medicine·I C Henderson, G P Canellos

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Citations

Jan 1, 1986·Cancer Chemotherapy and Pharmacology·W BradeK Herdrich
Feb 15, 1984·Klinische Wochenschrift·G A Nagel
Jan 1, 1984·Breast Cancer Research and Treatment·G F Beadle, J R Harris
Jul 1, 1989·Breast Cancer Research and Treatment·F HabibollahiR D Rubens
Sep 1, 1989·Cancer Treatment Reviews·F Habibollahi, I S Fentiman
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B OttevangerL V Beex
Sep 29, 1983·The New England Journal of Medicine·L R ProsnitzJ B Weissberg
Apr 14, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Pauline T TruongUNKNOWN Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
Mar 1, 1983·International Journal of Radiation Oncology, Biology, Physics·G Bonadonna, P Valagussa
Mar 1, 1983·International Journal of Radiation Oncology, Biology, Physics·J R Harris, S Hellman
Jan 1, 1983·International Journal of Radiation Oncology, Biology, Physics·A SulkesZ Fuks
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·B FowbleR Goodman
Jan 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J Boyages, A O Langlands
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·T A BuchholzT W Griffin
May 1, 1987·Current Problems in Cancer·I C Henderson
Dec 21, 2013·CA: a Cancer Journal for Clinicians·Reshma Jagsi
Dec 1, 1983·European Journal of Cancer & Clinical Oncology·H T Mouridsen, T Palshof
Mar 16, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·T T T VuL Paszat
Feb 15, 1984·Klinische Wochenschrift·H Vorherr
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M BontenbalJ G Klijn
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J WhelanM L Levine
Jan 1, 1996·Acta Oncologica·L E Rutqvist

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