A Randomized Comparison of Aripiprazole and Risperidone for the Acute Treatment of First-Episode Schizophrenia and Related Disorders: 3-Month Outcomes

Schizophrenia Bulletin
Delbert G RobinsonAnil K Malhotra

Abstract

Research findings are particularly important for medication choice for first-episode patients as individual prior medication response to guide treatment decisions is unavailable. We describe the first large-scale double-masked randomized comparison with first-episode patients of aripiprazole and risperidone, 2 commonly used first-episode treatment agents. One hundred ninety-eight participants aged 15-40 years with schizophrenia, schizophreniform disorder, schizoaffective disorder or psychotic disorder Not Otherwise Specified, and who had been treated in their lifetime with antipsychotics for 2 weeks or less were randomly assigned to double-masked aripiprazole (5-30 mg/d) or risperidone (1-6 mg/d) and followed for 12 weeks. Positive symptom response rates did not differ (62.8% vs 56.8%) nor did time to response. Aripiprazole-treated participants had better negative symptom outcomes but experienced more akathisia. Body mass index change did not differ between treatments but advantages were found for aripiprazole treatment for total and low-density lipoprotein cholesterol, fasting glucose, and prolactin levels. Post hoc analyses suggested advantages for aripiprazole on depressed mood. Overall, if the potential for akathisia is a c...Continue Reading

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Citations

Sep 27, 2015·Schizophrenia Bulletin·Joey W TrampushAnil K Malhotra
Aug 25, 2016·Neurology and Therapy·Benedicto Crespo-FacorroJacqueline Mayoral-van Son
Mar 16, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deepak K SarpalAnil K Malhotra
Jul 14, 2017·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Gary RemingtonMichael Teehan
Jan 13, 2018·Annual Review of Clinical Psychology·Lisa B DixonJohn M Kane
Aug 16, 2018·CNS Spectrums·Henry A NasrallahPeter J Weiden
Sep 15, 2018·The International Journal of Neuropsychopharmacology·Marcos Gómez-RevueltaBenedicto Crespo-Facorro
Jul 18, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philipp HomanAnil K Malhotra
Jul 8, 2020·Journal of Child and Adolescent Psychopharmacology·Jerome H TaylorMichael H Bloch
Feb 23, 2020·Frontiers in Pharmacology·Qingqing XuShunying Yu
Jan 27, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philipp HomanAnil K Malhotra
Aug 18, 2020·Schizophrenia Bulletin Open·Melanie Blair ThiesAnil K Malhotra
May 13, 2017·International Journal of Psychiatry in Clinical Practice·Alkomiet HasanUNKNOWN WFSBP Task Force on Treatment Guidelines for Schizophrenia
Mar 29, 2018·Current Psychiatry Reports·Jian-Ping Zhang, Anil K Malhotra
Feb 14, 2021·Psychopharmacology·Vjekoslav PeitlDalibor Karlović
Feb 17, 2021·The Cochrane Database of Systematic Reviews·Masuma Pervin MishuNajma Siddiqi
Mar 9, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marcos Gómez-RevueltaBenedicto Crespo-Facorro
Mar 24, 2021·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Wang ZhenhuaJin Haiying

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