A randomized comparison of efficacy and safety of intralesional triamcinolone injection and clobetasol propionate ointment for psoriatic nails

The Journal of Dermatological Treatment
Einapak BoontaveeyuwatChanisada Wongpraparut

Abstract

Even though the traditional therapy for nail psoriasis has been used for decades, no randomized, controlled trial of such treatment has been conducted to date. To evaluate the efficacy and safety of intralesional triamcinolone injections compared with 0.05% clobetasol ointment for psoriatic nails. Psoriasis patients, each with three fingernails with similar degrees of severity, were randomly recruited for intralesional triamcinolone injection group, 0.05% clobetasol ointment group, and a control group. The target Nail Psoriasis Severity Index (NAPSI) score of each finger was evaluated, any adverse effects were recorded, and photographs were taken. Forty-eight affected nails were analyzed. At the second month, a significantly greater reduction of the target NAPSI score was observed in the injection group compared to the control group (p = .003). There was a greatest reduction of the score in the following two month-period, which showed significant difference from the topical group (p = .003) and the control group (p = < .001). The score of the injection group, however, subsequently rose at the six-month visit so that there was no longer any statistically-significant difference between the three groups. In spite of its temporary ...Continue Reading

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Citations

Nov 28, 2018·MMW Fortschritte der Medizin·Dietrich Abeck
Mar 23, 2021·Dermatologic Clinics·Jose W Ricardo, Shari R Lipner
May 13, 2021·Dermatology and Therapy·Edward HadelerWilson Liao
Feb 17, 2021·The Journal of Rheumatology·Gurjit S KaeleyCatherine J Bakewell
Dec 5, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christoph R LöserGalina Balakirski

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