A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos

Transactions of the Royal Society of Tropical Medicine and Hygiene
Mayfong MayxayNicholas J White

Abstract

Between June and October 2000 we conducted the first randomized trial in Laos comparing chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated Plasmodium falciparum malaria (n = 29, 42-d follow-up, age > 5 years). The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently.

References

Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·K SilamutN J White
May 18, 1999·British Medical Bulletin·N J White
Jul 21, 2001·The American Journal of Tropical Medicine and Hygiene·H TomaS Inthakone
Oct 25, 2002·Annals of Tropical Medicine and Parasitology·J-P GuthmannD Legros

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Citations

Oct 27, 2004·Antimicrobial Agents and Chemotherapy·Kasia StepniewskaNicholas J White
Apr 21, 2007·Tropical Medicine & International Health : TM & IH·Mayfong MayxayPaul N Newton

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