Abstract
To determine if 1-minute instillation of Curosurf via a dual-lumen endotracheal tube without interruption of mechanical ventilation could decrease the incidence of hypoxia (drop in oxygen saturation [SaO2] to <80%, or of transcutaneous partial pressure of oxygen [PtcO2] to <50 mm Hg [6.6 kPa]) and bradycardia (heart rate below 80 beats/minute) at dosing, without affecting the efficacy of the standard bolus delivery. Prospective, multicenter, randomized, nonblinded clinical trial. Neonatal intensive care units of the Spanish Surfactant Collaborative Group. One hundred ninety-eight infants (birth weight 600-2000 g) with respiratory distress syndrome needing mechanical ventilation with a fraction of inspired oxygen [FIO2] 0.40 were randomized before 24 hours to receive 200 mg/kg of Curosurf, either by bolus instillation (n = 99) or by a simplified dosing technique (n = 99), giving the full dose in 1 minute via a dual-lumen endotracheal tube without positioning, interruption of mechanical ventilation, or bagging. Two additional doses (100 mg/kg) were given within 12 and 24 hours of first dose, by the same method, if the infant still needed mechanical ventilation and had a FIO2 0.30. The effects of both procedures on the incidence o...Continue Reading
References
May 1, 1992·Pediatric Research·J M DavisB S Greenspan
Oct 1, 1991·Archives of Disease in Childhood·F CowanM Silverman
Feb 1, 1991·Journal of Applied Physiology·J F LewisB Tabor
Mar 1, 1990·The American Review of Respiratory Disease·N GilliardR G Spragg
Aug 1, 1989·European Journal of Pediatrics·G JorchL Gortner
Jan 1, 1989·Developmental Pharmacology and Therapeutics·H L Halliday
Jan 12, 1980·Lancet·T FujiwaraT Abe
Mar 1, 1984·The Journal of Clinical Investigation·A JobeS Jones
Sep 1, 1994·Acta Paediatrica·A H BellG Greisen
Jan 1, 1994·Biology of the Neonate·M ReyM Obladen
Jan 1, 1994·Journal of Applied Physiology·T UedaA H Jobe
Nov 1, 1993·The American Review of Respiratory Disease·J F Lewis, L McCaig
Oct 1, 1993·Pediatric Research·H SegererB Lachmann
Jan 1, 1993·The American Review of Respiratory Disease·J F Lewis, A H Jobe
Mar 1, 1993·The Journal of Pediatrics·E M ZolaM M Wyza
Jan 1, 1996·Biology of the Neonate·H SegererM Obladen
Mar 1, 1996·The Journal of Pediatrics·M L HudakP Montgomery
Aug 1, 1996·Pediatric Research·A MoenO D Saugstad
Oct 1, 1995·Acta Anaesthesiologica Scandinavica·F J AlvarezA Valls-i-Soler
Apr 1, 1997·Pediatric Research·A MoenO D Saugstad
Jul 1, 1997·Acta Paediatrica·A Valls-i-SolerE Gastiasoro
Citations
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Sean B Ainsworth, David W A Milligan
Feb 26, 2004·Paediatric Respiratory Reviews·Colin Morley, Peter Davis
Dec 14, 2012·Journal of Human Genetics·Mohamed Ali MosratiSaber Masmoudi
Mar 29, 2014·Nature Neuroscience·Mariano SigmanSidarta Ribeiro
Aug 8, 2013·Therapeutic Delivery·Nashwa El-GendyPrajnaparamita Dhar
Jul 6, 2014·Human Molecular Genetics·Qing SangLei Wang
Jun 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·H L Halliday
Apr 5, 2015·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·F Castillo SalinasUNKNOWN en representación del Grupo Respiratorio y Surfactante de la Sociedad Española de Neonatología
Jun 12, 2004·The Journal of Pediatrics·Jeffrey R KaiserD Keith Williams
Sep 26, 2001·Clinics in Perinatology·G K Suresh, R F Soll
Nov 20, 2016·Pediatric Research·Katarzyna E Wroblewska-SeniukJan Mazela
Jul 12, 2017·Neural Plasticity·Xue GaoPu Dai
Sep 29, 2021·American Journal of Perinatology·Handan BezirganogluGozde Kanmaz Kutman