PMID: 9533371Apr 9, 1998Paper

A randomized comparison of surfactant dosing via a dual-lumen endotracheal tube in respiratory distress syndrome. The Spanish Surfactant Collaborative Group

Pediatrics
A Valls-i-SolerV Carretero

Abstract

To determine if 1-minute instillation of Curosurf via a dual-lumen endotracheal tube without interruption of mechanical ventilation could decrease the incidence of hypoxia (drop in oxygen saturation [SaO2] to <80%, or of transcutaneous partial pressure of oxygen [PtcO2] to <50 mm Hg [6.6 kPa]) and bradycardia (heart rate below 80 beats/minute) at dosing, without affecting the efficacy of the standard bolus delivery. Prospective, multicenter, randomized, nonblinded clinical trial. Neonatal intensive care units of the Spanish Surfactant Collaborative Group. One hundred ninety-eight infants (birth weight 600-2000 g) with respiratory distress syndrome needing mechanical ventilation with a fraction of inspired oxygen [FIO2] 0.40 were randomized before 24 hours to receive 200 mg/kg of Curosurf, either by bolus instillation (n = 99) or by a simplified dosing technique (n = 99), giving the full dose in 1 minute via a dual-lumen endotracheal tube without positioning, interruption of mechanical ventilation, or bagging. Two additional doses (100 mg/kg) were given within 12 and 24 hours of first dose, by the same method, if the infant still needed mechanical ventilation and had a FIO2 0.30. The effects of both procedures on the incidence o...Continue Reading

References

Oct 1, 1991·Archives of Disease in Childhood·F CowanM Silverman
Feb 1, 1991·Journal of Applied Physiology·J F LewisB Tabor
Jan 1, 1989·Developmental Pharmacology and Therapeutics·H L Halliday
Jan 1, 1994·Journal of Applied Physiology·T UedaA H Jobe
Nov 1, 1993·The American Review of Respiratory Disease·J F Lewis, L McCaig
Jan 1, 1993·The American Review of Respiratory Disease·J F Lewis, A H Jobe

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Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Sean B Ainsworth, David W A Milligan
Feb 26, 2004·Paediatric Respiratory Reviews·Colin Morley, Peter Davis
Dec 14, 2012·Journal of Human Genetics·Mohamed Ali MosratiSaber Masmoudi
Mar 29, 2014·Nature Neuroscience·Mariano SigmanSidarta Ribeiro
Aug 8, 2013·Therapeutic Delivery·Nashwa El-GendyPrajnaparamita Dhar
Jun 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·H L Halliday
Apr 5, 2015·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·F Castillo SalinasUNKNOWN en representación del Grupo Respiratorio y Surfactante de la Sociedad Española de Neonatología
Sep 26, 2001·Clinics in Perinatology·G K Suresh, R F Soll
Nov 20, 2016·Pediatric Research·Katarzyna E Wroblewska-SeniukJan Mazela

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