PMID: 8586825Sep 1, 1995Paper

A randomized comparison of the effect of four antihypertensive monotherapies on the subjective quality of life in previously untreated asymptomatic patients: field trial in general practice. The OCAPI Study Group. Optimiser le Choix d'un Anti-hypertenseur de Première Intention

Journal of Hypertension
J P BoisselP Gerini

Abstract

To assess the equivalence of four antihypertensive treatments in patients with mild-to- moderate hypertension, and to compare the effects of those drugs on the subjective quality of life and clinical safety. 653 patients aged > or = 18 years with untreated hypertension were randomly allocated to receive a combination of two diuretics (altizide and spironolactone), a beta-blocker (bisoprolol), a calcium antagonist (verapamil), or an angiotensin converting enzyme (ACE) inhibitor (enalapril). Follow-up lasted for 1 year. A composite outcome of the following measures was used to define success: attendance at the 12-month visit; at least nine supine DBP measurements during the study; and median supine DBP < 90 mmHg and a reduction of at least 10 mmHg compared with the baseline value. Failure was defined as one or more of those criteria not being fulfilled. Equivalence was concluded if the 95% confidence interval for the success rates differed between two groups by less than +/- 10%. Clinical safety and subjective quality of life were also assessed. No statistically significant differences in the change in DBP or systolic blood pressure were observed between the groups. The success rates were 43.9, 42.0, 32.5 and 43.9% in diuretic, b...Continue Reading

Citations

Feb 1, 2002·The Journal of Clinical Hypertension·Carlos CampoLuis M Ruilope
Dec 31, 1997·Journal of General Internal Medicine·R A Rossi, N R Every
Aug 7, 2003·Journal of Vascular and Interventional Radiology : JVIR·Mary Montrella Waybill, Peter N Waybill
Aug 17, 2006·Scandinavian Journal of Medicine & Science in Sports·F J Cuevas FernandezA Aguirre-Jaime
Apr 12, 2000·The American Journal of Medicine·P Rudd
Jul 30, 2017·The Australian and New Zealand Journal of Psychiatry·Daniel J BrownsteinBrisa S Fernandes
Apr 29, 2000·Annals of Internal Medicine·W L GreeneA R Feinstein
Oct 18, 2003·The Journal of Clinical Hypertension·Michael A WeberThomas D Giles
Oct 11, 2001·Journal of Hypertension·A Roca-CusachsM Roset
Apr 28, 2006·Internal Medicine Journal·L SimonellaG Andrews
Jul 4, 2001·Blood Pressure Monitoring·B H LaskoS Bonnefis-Boyer
Oct 27, 2016·Clinical Pharmacology in Drug Development·Ulrike Gottwald-HostalekSteven Hildemann

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