A randomized comparison of triple-site versus dual-site ventricular stimulation in patients with congestive heart failure

Journal of the American College of Cardiology
C LeclercqTRIP-HF (Triple Resynchronization In Paced Heart Failure Patients) Study Group

Abstract

We compared the effects of triple-site versus dual-site biventricular stimulation in candidates for cardiac resynchronization therapy. Conventional biventricular stimulation with a single right ventricular (RV) and a single left ventricular (LV) lead is associated with persistence of cardiac dyssynchrony in up to 30% of patients. This multicenter, single-blind, crossover study enrolled 40 patients (mean age 70 +/- 9 years) with moderate-to-severe heart failure despite optimal drug treatment, a mean LV ejection fraction of 26 +/- 11%, and permanent atrial fibrillation requiring cardiac pacing for slow ventricular rate. A cardiac resynchronization therapy device connected to 1 RV and 2 LV leads, inserted in 2 separate coronary sinus tributaries, was successfully implanted in 34 patients. After 3 months of biventricular stimulation, the patients were randomly assigned to stimulation for 3 months with either 1 RV and 2 LV leads (3-V) or to conventional stimulation with 1 RV and 1 LV lead (2-V), then crossed over for 3 months to the alternate configuration. The primary study end point was quality of ventricular resynchronization (Z ratio). Secondary end points included reverse LV remodeling, quality of life, distance covered during ...Continue Reading

References

Sep 15, 1993·The American Journal of Cardiology·T H LeeJ A Walden
Oct 5, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·J A Salerno-Uriarte, M Tritto
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
Apr 2, 2003·Circulation·Martin G St John SuttonUNKNOWN Multicenter InSync Randomized Clinical Evaluation (MIRACLE) Study Group
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Jun 11, 2004·Pacing and Clinical Electrophysiology : PACE·Massimo SassaraFabrizio Sgreccia
Nov 16, 2004·The American Journal of Cardiology·Selwyn P WongHarvey D White
Dec 25, 2004·European Heart Journal·M BrignoleUNKNOWN Optimal Pacing SITE (OPSITE) Study Investigators
Nov 24, 2005·Journal of Cardiovascular Electrophysiology·Rahul N DoshiUNKNOWN PAVE Study Group
Jan 31, 2006·The American Journal of Cardiology·Gabe B BleekerCheuk-Man Yu

❮ Previous
Next ❯

Citations

Feb 24, 2011·Herzschrittmachertherapie & Elektrophysiologie·H-H Minden
Mar 23, 2011·Herzschrittmachertherapie & Elektrophysiologie·C W Israel
Feb 23, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takashi Nishimura, Shunei Kyo
Jan 12, 2012·Journal of Cardiovascular Translational Research·Sylvain PlouxPierre Bordachar
Sep 29, 2011·European Heart Journal·Jagmeet P Singh, Daniel Gras
Jan 29, 2013·European Heart Journal·Cheuk-Man Yu, David L Hayes
Nov 5, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Islem SanaaJean-Claude Deharo
Nov 5, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·John M Morgan, Victoria Delgado
Nov 3, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Radu VatasescuJosep Brugada
Apr 20, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·David SchwartzmanSamir Saba
Nov 3, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Matthew R GinksC Aldo Rinaldi
Aug 30, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jean-Claude DaubertChristian Tobias Torp-Pedersen
Mar 1, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bernard ThibaultTaraneh G Farazi
May 23, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michio OganoKyoichi Mizuno
Nov 26, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Paul W X FoleyFrancisco Leyva
Nov 11, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Francisco Leyva
Nov 10, 2010·Anesthesia and Analgesia·Jonathan K Ho, Aman Mahajan
Mar 15, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·C Aldo RinaldiTasneem Z Naqvi
Mar 19, 2014·Current Treatment Options in Cardiovascular Medicine·Pierre BordacharSylvain Ploux
Feb 15, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Anoop K ShettyC Aldo Rinaldi
Oct 19, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Sylvain PlouxPierre Bordachar
Oct 11, 2014·Future Cardiology·James H P Gamble, Tim R Betts
Dec 25, 2010·Heart Failure Reviews·Dan Blendea, Jagmeet P Singh
Oct 20, 2011·Heart Failure Reviews·Peter J Cowburn, Christophe Leclercq
Oct 15, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Sylvain PlouxFrits W Prinzen
May 15, 2013·Current Problems in Cardiology·Srikant Duggirala, Byron K Lee
Sep 4, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jean-Claude DaubertJose Luis Zamorano
Aug 7, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mitsuaki ItohKen-ichi Hirata
Apr 24, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Derek V ExnerJagmeet P Singh
Jan 1, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fraz UmarFrancisco Leyva
Aug 23, 2011·Lancet·Johannes Holzmeister, Christophe Leclercq
Sep 2, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Frederic AnselmeArnaud Savouré
Aug 4, 2016·Indian Pacing and Electrophysiology Journal·Elisa EbrilleSamuel J Asirvatham
Jul 5, 2008·Heart Failure Clinics·Leonard M RademakersFrits W Prinzen
Jul 29, 2009·Journal of Cardiovascular Electrophysiology·Radosław LenarczykZbigniew Kalarus
Apr 14, 2012·European Journal of Heart Failure·Marcus J Hof, Alexander H Maass
Nov 2, 2011·Pacing and Clinical Electrophysiology : PACE·Steven A NiedererC A Rinaldi
Dec 1, 2011·Pacing and Clinical Electrophysiology : PACE·Anoop K ShettyC Aldo Rinaldi
Feb 9, 2012·European Journal of Heart Failure·Dominic P S RogersAnthony W C Chow
Mar 30, 2010·Pacing and Clinical Electrophysiology : PACE·Melissa E Harding, Eugen C Palma
Jun 18, 2010·Cardiovascular Therapeutics·Suraj KapaSamuel J Asirvatham
Nov 26, 2015·Cardiac Electrophysiology Clinics·Attila RokaJagmeet Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Radoslaw LenarczykZbigniew Kalarus
The New England Journal of Medicine
Michael R BristowComparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
The New England Journal of Medicine
John G F ClelandCardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
© 2022 Meta ULC. All rights reserved