A randomized controlled clinical trial of 4% sodium citrate versus heparin as locking solution for temporary dialysis catheters among hemodialysis patients


Clinical Nephrology
Abdel Basset E Abdel AzimHala M Ali

Abstract

Limited reports are available on the role of 4% citrate as a locking solution for temporary dialysis catheters. Hence, the aim of this study is to investigate the role of 4% citrate vs. heparin 5,000 µ/mL as a catheter-locking solution in a randomized controlled trial. The trial was conducted in Egypt where the use of non-tunneled temporary catheters is prevalent compared to tunneled long-term catheters. The efficacy of catheter-locking solutions was compared regarding observation of rate of catheter dysfunction, low-flow pump, fever as a sign of central-line blood-stream infection (CLBSI), catheter-site infection, thrombosis, local bleeding, and systemic bleeding in each group of the study. Each group consisted of 105 patients. The number of patients who developed CLBSI in the citrate group was 11 (10.5%) compared to 23 (21.9%) in the heparin group (p < 0.025). The number of patients who developed catheter dysfunction in the citrate group was similar to those in the heparin group. The incidence of catheter-site infection, thrombosis, and local bleeding in the citrate group was similar to that in the heparin group. Citrate 4% lock solution is equally effective as heparin in maintaining catheter patency in dialysis patients. It ...Continue Reading

Citations

Feb 7, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·George AlvarezJuan G Posadas-Calleja
Jul 16, 2019·The Journal of International Medical Research·He-Ming HuangChang-Jin Shi
Dec 21, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Kaixiang ShengJianghua Chen

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