PMID: 11332926May 3, 2001Paper

A randomized controlled clinical trial of zinc, vitamin A or both in undernourished children with persistent diarrhea in Bangladesh

Acta Paediatrica
U H KhatunS K Roy

Abstract

In a double-blind randomized controlled clinical trial, moderately malnourished Bangladeshi children (61-75% of the median weight/age) were studied for the effect of zinc and/or vitamin A supplementation on the clinical outcome of persistent diarrhea. Children 6 mo to 2 y of age with diarrhea for more than 14 d were randomly allocated into 4 groups of 24 receiving a multivitamin syrup and (i) zinc (20 mg elemental), (ii) vitamin A, (iii) both zinc and vitamin A, or (iv) neither, in 2 doses daily for 7 d. Clinical data on recovery and on stool output, consistency and frequency were recorded for 7 d, and weight change from day 1 to day 7 was assessed. The baseline characteristics of the four study groups were comparable. The mean daily stool outputs from days 2 to 7 of therapy were significantly less in the zinc and zinc plus vitamin A groups, but not in the vitamin A group, in comparison with the control group. In children receiving zinc, the cumulative stool weight in the 7 d was 39% less than in the control group (p < 0.001) and 32% less than in the vitamin A group (p = 0.006). The cumulative stool weight in the zinc plus vitamin A group was 24% less than in the control group (p < 0.001), but the 14% lower output than in the v...Continue Reading

Citations

May 14, 2003·The Journal of Nutritional Biochemistry·Sang K Noh, Sung I Koo
Jul 14, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christa L Fischer Walker, Robert E Black
Apr 2, 2010·International Journal of Epidemiology·Christa L Fischer Walker, Robert E Black
May 2, 2002·Nutrition Today·Robert E. Black, Stanley G. Miguel
Sep 7, 2006·Journal of Pediatric Gastroenterology and Nutrition·Christa L Fischer WalkerUNKNOWN Zinc Study Group
Jun 11, 2004·Annual Review of Nutrition·Christa Fischer Walker, Robert E Black
Feb 28, 2004·Lancet·Nikhil Thapar, Ian R Sanderson
Jan 22, 2008·Lancet·Robert E BlackUNKNOWN Maternal and Child Undernutrition Study Group
Jan 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Aliya NaheedAbdullah H Baqui
Dec 21, 2016·The Cochrane Database of Systematic Reviews·Marzia Lazzerini, Humphrey Wanzira
Jun 30, 2014·The Cochrane Database of Systematic Reviews·Anjana Gulani, Harshpal S Sachdev

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