PMID: 11339416May 8, 2001Paper

A randomized controlled comparison of three quadruple therapy regimens in a population with low Helicobacter pylori eradication rates

Journal of Gastroenterology and Hepatology
R SotudehmaneshM R Eshraghian

Abstract

We sought to compare the efficacy and tolerability of an omeprazole/clarithromycin/bismuth/tetracycline-based quadruple therapy to that of a ranitidine/metronidazole/bismuth/tetracycline-based quadruple therapy of 2 or 3 weeks duration in a population with a high prevalence of metronidazole-resistant Helicobacter pylori and low triple therapy eradication rates. Two hundred and twenty-one patients who presented endoscopically proven duodenal ulcers and a positive rapid urease test were randomized to receive either: (i) omeprazole 20 mg b.i.d., clarithromycin 250 mg b.i.d., bismuth subcitrate 240 mg b.i.d. and tetracycline 500 mg b.i.d (OCBT) for 2 weeks; (ii) ranitidine 300 mg b.i.d., metronidazole 500 mg b.i.d, bismuth subcitrate 240 mg b.i.d. and tetracycline 500 mg b.i.d. (RMBT2) for 2 weeks; or (iii) ranitidine 300 mg b.i.d., metronidazole 500 mg b.i.d, bismuth subcitrate 240 mg b.i.d. and tetracycline 500 mg b.i.d. (RMBT3) for 3 weeks. Patients were interviewed 2 weeks after the completion of therapy to review compliance and side-effects. Eradication of H. pylori was assessed 8 weeks after the completion of therapy with the use of a 14C-urea breath test. The per-protocol eradication rate was significantly higher with OCBT (...Continue Reading

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Citations

Mar 19, 2003·Alimentary Pharmacology & Therapeutics·A ZulloS Morini
Aug 19, 2014·World Journal of Gastroenterology : WJG·Hafez FakheriReza Malekzadeh
Jul 14, 2020·Journal of Chemotherapy·Samin AlihosseiniHamed Ebrahimzadeh Leylabadlo
Apr 24, 2018·Middle East Journal of Digestive Diseases·Hafez FakheriZohreh Bari

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