A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Hao LiLing Cui

Abstract

To observe the effect and explore the mechanism of Huannao Yicong capsule in treating senile patients with mild cognitive impairment (MCI). The investigational drugs were packed by blind method. A randomized, double-blind and controlled trial was conducted on ninety senile patients with MCI. Other forty-five senile healthy persons were recruited to the healthy control group. The ninety senile patients were randomly divided into the Huannao Yicong capsule-treated group (45 patients administered with three Huannao Yicong capsules and two aniracetam capsule analogues) and aniracetam-treated group (45 patients treated with two aniracetam capsules and three Huannao Yicong capsule analogues). Patients in the two groups were treated three times daily for 16 weeks. Memory, traditional Chinese medicine syndrome, cerebral blood flow, free radicals and inflammatory mediators, such as superoxide dismutase (SOD), malondialdehyde (MDA), acetylcholinesterase (AchE), interleukin-1alpha (IL-1alpha) and interleukin-6 (IL-6) were determined before and after the treatment. Blood lipids, including triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein A-1 ...Continue Reading

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Citations

Oct 3, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Claudia CooperGill Livingston
Jun 30, 2014·Journal of Psychiatric Research·Wing-Fai YeungBacon Fung-Leung Ng
Jun 25, 2013·Maturitas·Antonio González-SarríasJuan Carlos Espín
Jan 6, 2017·Scientific Reports·Li HuiGuang Zhong Yin
Feb 10, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Meixia LiuHao Li
Apr 7, 2020·Clinical and Experimental Pediatrics·Su Yeong Kim, Dae Yong Yi

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