A randomized controlled efficacy trial of mindfulness-based stress reduction compared with an active control group and usual care for fibromyalgia: the EUDAIMON study

Pain
Adrián Pérez-ArandaJuan V Luciano

Abstract

Fibromyalgia (FM) syndrome represents a great challenge for clinicians and researchers because the efficacy of currently available treatments is limited. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for reducing functional impairment as well as the role of mindfulness-related constructs as mediators of treatment outcomes for people with FM. Two hundred twenty-five participants with FM were randomized into 3 study arms: MBSR plus treatment-as-usual (TAU), FibroQoL (multicomponent intervention for FM) plus TAU, and TAU alone. The primary endpoint was functional impact (measured with the Fibromyalgia Impact Questionnaire Revised), and secondary outcomes included "fibromyalginess," anxiety and depression, pain catastrophising, perceived stress, and cognitive dysfunction. The differences in outcomes between groups at post-treatment assessment (primary endpoint) and 12-month follow-up were analyzed using linear mixed-effects models and mediational models through path analyses. Mindfulness-based stress reduction was superior to TAU both at post-treatment (large effect sizes) and at follow-up (medium to large effect sizes), and MBSR was also superior to FibroQoL post-treatment (medium to large effect si...Continue Reading

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Citations

Feb 6, 2020·Journal of Clinical Medicine·Albert Feliu-SolerJuan V Luciano
Sep 25, 2020·Plastic and Reconstructive Surgery·Pauline Joy F Santos, Gregory R D Evans
Jan 6, 2021·International Journal of Environmental Research and Public Health·Adrián Pérez-ArandaJuan V Luciano
Mar 8, 2021·The Journal of Pain : Official Journal of the American Pain Society·Caroline MaindetJean-Luc Bosson
Mar 27, 2021·International Journal of Clinical and Health Psychology : IJCHP·Adrián Pérez-ArandaJesus Montero-Marin
Jul 3, 2021·Healthcare·Lizzette Gómez-de-Regil

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