A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™) in eliminating fleas in client-owned dogs in the USA

Parasites & Vectors
Daniela KaradzovskaSteve Nanchen

Abstract

Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelio™, Elanco) administered orally to dogs, produces rapid flea and tick knockdown and sustained speed of kill for at least a month post-treatment with a wide safety margin. A field study was undertaken to validate pre-clinical results. Dogs were enrolled at 10 veterinary clinics across the United States. Qualifying households containing up to three dogs and one primary dog with at least 10 fleas were randomized 2:1 to receive lotilaner (Credelio™, Elanco) at the recommended minimum dose of 20 mg/kg, or afoxolaner (Nexgard®, Merial), administered per label, to give a minimum dose of 2.5 mg/kg. Treatments were dispensed on Days 0, 30 and 60 for administration by owners; all household dogs received the same treatment as the primary dog. Post-enrollment flea and tick counts were made on primary dogs on Days 30, 60 and 90, and all dogs were assessed for tablet palatability and safety. For efficacy assessments, data were used from 111 lotilaner-treated dogs and 50 afoxolaner-treated dogs; for safety, 197 and 86 dogs, respectively. Percent reductions from baseline in geometric mean flea counts for the lotilaner group were 99.3, 99.9 and 100% on Days 30, 60 and ...Continue Reading

References

Jan 1, 1997·Annual Review of Entomology·M K Rust, M W Dryden
Oct 21, 2005·Archives of Environmental Contamination and Toxicology·S K ObendorfT Dokuchayeva
Nov 26, 2009·The Veterinary Clinics of North America. Small Animal Practice·Byron L Blagburn, Michael W Dryden
Aug 12, 2015·BMC Veterinary Research·Patrick HenselCraig Griffin
Aug 16, 2015·BMC Veterinary Research·Thierry OlivryUNKNOWN International Committee on Allergic Diseases of Animals
Nov 2, 2017·Parasites & Vectors·Emmanuelle A Kuntz, Srinivas Kammanadiminti
Nov 2, 2017·Parasites & Vectors·Daniela CavalleriSteve Nanchen

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Citations

Nov 2, 2017·Parasites & Vectors·Céline E ToutainMartin Jung
Jul 14, 2018·Parasites & Vectors·Céline E ToutainMartin Jung
Nov 2, 2017·Parasites & Vectors·Susan E Little
Jul 14, 2018·Parasites & Vectors·Emmanuelle A Kuntz, Srinivas Kammanadiminti
Oct 3, 2020·Insects·Michael K Rust
Oct 9, 2020·ChemMedChem·Gulshan Kumar, Ravi Shankar
May 29, 2021·Parasites & Vectors·Donato Traversa
Jan 23, 2022·Parasites & Vectors·Robert LavanKathleen Heaney

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