A randomized controlled pilot trial of game-based training in individuals with spinocerebellar ataxia type 3

Scientific Reports
Ray-Yau WangYea-Ru Yang

Abstract

Exergames are interactive video games used for exercise and may have therapeutic value in people with degenerative ataxia. The purpose of this study was to investigate potential effects of exergaming training on cerebellar ataxia in people with spinocerebellar ataxia type 3 (SCA3). Nine individuals with SCA3 were recruited and randomized to either exergaming or conventional group for a 4-week training period. The severity of ataxia was measured as the primary outcome by the Scale for the Assessment and Rating of Ataxia (SARA) and by the directional control of the limit of stability test. The secondary outcomes included upper-limb function and gait performance. After training, participants in the exergaming group had a significant decrease in the total SARA score and the gait-posture SARA subscore. Participants in the conventional training group did not show a significant improvement in selected outcome measures after the 4-week training period. No significant difference was found between groups for any of these measures. Our results suggested that the exergaming training program significantly decreased ataxia. These results support implementation of exergaming training for people with SCA3.

References

Jun 14, 2006·Neurology·T Schmitz-HübschRoberto Fancellu
Feb 10, 2007·Nature Clinical Practice. Neurology·Sub H Subramony
May 23, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Anja WeyerThomas Klockgether
Feb 24, 2010·Neurology·T Schmitz-HübschT Klockgether
Aug 26, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Winfried IlgMatthis Synofzik
Dec 6, 2011·Neurorehabilitation and Neural Repair·Ichiro MiyaiUNKNOWN Cerebellar Ataxia Rehabilitation Trialists Collaboration
Jun 19, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·José Luiz PedrosoOrlando Graziani P Barsottini
Mar 4, 2014·Annals of Physical and Rehabilitation Medicine·A MarquerD Pérennou
Jan 13, 2018·Frontiers in Human Neuroscience·Tjitske F LawermanDeborah A Sival

❮ Previous
Next ❯

Citations

Nov 7, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jorge Diogo Da SilvaPatrícia Maciel
Dec 31, 2019·BioMed Research International·Elisabetta PeriEmilia Biffi
Dec 29, 2020·Frontiers in Physiology·Miguel Fernández-de la TorreMaría Morán
Aug 5, 2021·Journal of Cognitive Neuroscience·William Saban, Richard B Ivry
Oct 11, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Yaimeé Vázquez-MojenaLuis Velázquez-Pérez

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02900508

Software Mentioned

Exergames
GAITRite
SPSS

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.