A Randomized Controlled Study to Examine the Effect of a Lifestyle Modification Program in OSA

Chest
Susanna S S NgDavid S C Hui

Abstract

Obesity is an important risk factor for OSA. This study aimed to assess the effect of weight reduction through a lifestyle modification program (LMP) on patients with moderate to severe OSA. This was a parallel group, randomized controlled trial. Altogether, 104 patients with moderate to severe OSA diagnosed on portable home sleep monitoring were randomized to receive a dietician-led LMP or usual care for 12 months. The primary outcome was reduction of apnea-hypopnea index (AHI) at 12 months as assessed by portable home sleep monitoring. In the intention-to-treat analysis (ITT), LMP (n = 61) was more effective in reducing AHI from baseline (16.9% fewer events in the LMP group vs 0.6% more events in the control group, P = .011). LMP was more effective in reducing BMI (-1.8 kg/m2, 6.0% of the initial BMI; -0.6 kg/m2, 2.0% of the initial BMI in control group; P < .001). The reduction in daytime sleepiness as assessed by Epworth Sleepiness Scale was not significant in ITT but was more in the LMP group (-3.5 in the LMP group vs -1.1 in the control group, P = .004) by treatment per protocol analysis. There was modest improvement in mental health in the Short Form Health Survey. Eating behavior was improved with increased intake of pr...Continue Reading

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Citations

Nov 4, 2015·Chest·Sanjay R Patel, Reena Mehra
Dec 10, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Susanna S S NgDavid S C Hui
Jan 25, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·W L NgA Peeters
Jan 5, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Almudena Carneiro-BarreraGualberto Buela-Casal
Feb 1, 2020·International Journal of Clinical Practice·Izolde BouloukakiSophia Schiza
Feb 1, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Carla López-PadrósCarmen Monasterio
Feb 7, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Sören Spörndly-NeesHelena Igelström
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Oct 16, 2020·American Journal of Respiratory and Critical Care Medicine·Anna E B McLeanBrendon J Yee
Mar 12, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Sean M CaplesSarah D Hashmi
May 1, 2021·Journal of Clinical Medicine·Marta Stelmach-MardasMarcin Mardas

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