A randomized-controlled trial comparing cadexomer iodine and nanocrystalline silver on the healing of leg ulcers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Charne Nicole MillerNick Santamaria

Abstract

Chronic leg ulcers are a debilitating, often painful, and costly condition. Leg ulcer healing may be impaired by bacterial colonization, which, unless effective intervention is instigated, can lead to infection. Although it is generally agreed that an antimicrobial dressing is clinically indicated when a wound becomes critically colonized, there is currently no agreement on what constitutes the best practice in the use of antimicrobials. This research compared the effectiveness of two commonly used antimicrobials: nanocrystalline silver and cadexomer iodine. A randomized-controlled trial was conducted in which 281 community nursing clients with leg ulcers compromised by bacterial burden were randomly assigned to have their wounds treated with either silver or iodine dressings. Sixty-four percent of ulcers healed within 12 weeks. The performance of each of the two antimicrobials was comparable in terms of overall healing rate and the number of wounds healed. However, use of silver compounds was associated with a quicker healing rate during the first 2 weeks of treatment and in wounds that were larger, older, and had more exudate. This trial provides some insights as to circumstances in which one product may be preferred over the...Continue Reading

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References

Oct 1, 1992·Journal of Internal Medicine·J TyrrellJ Feely
Nov 1, 1987·Clinical and Experimental Dermatology·C MossS Shuster
Nov 1, 1988·The Journal of International Medical Research·H Laudanska, B Gustavson
Aug 1, 1983·Journal of the American Geriatrics Society·S MobergA Holst
Dec 2, 1998·Journal of Wound Care·P J Franks, C J Moffatt
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·S E GardnerB N Doebbeling
Feb 23, 2002·Collegian : Journal of the Royal College of Nursing, Australia·N Santamaria, L Clayton
Sep 24, 2002·Vascular and Endovascular Surgery·P MadhavanG Shanik
May 20, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Christine J MoffattPeter J Franks
Oct 21, 2004·The Cochrane Database of Systematic Reviews·N AdhikariM O Meade
May 6, 2005·The International Journal of Lower Extremity Wounds·Christine Moffatt
May 3, 2006·International Wound Journal·David L SteedMartin C Robson
May 26, 2006·International Wound Journal·Gregory S SchultzUNKNOWN Wound Bed Advisory Board Members
Jun 2, 1994·Journal of Wound Care·K F Cutting, K G Harding

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Citations

Oct 7, 2011·Molecular Pharmaceutics·Ruth Duncan, Rogerio Gaspar
Dec 1, 2011·The Journal of the American College of Clinical Wound Specialists·Thirumurugan GunasekaranMagharla Dasaratha Dhanaraju
Jan 5, 2013·International Wound Journal·David J LeaperRebecca Drake
Nov 17, 2010·International Wound Journal·Charne Nicole MillerNick Santamaria
Jan 22, 2011·International Wound Journal·David Leaper, Rebecca Drake
Apr 5, 2016·ACS Applied Materials & Interfaces·Madasamy ParaniAkhilesh K Gaharwar
Mar 30, 2012·Journal of Plastic Surgery and Hand Surgery·Toshihiro FujiwaraMasao Kakibuchi
Jun 24, 2015·Journal of Colloid and Interface Science·Stefania MuraAntonella Lugliè
Jan 8, 2013·Nano Today·Lara YildirimerAlexander M Seifalian
Oct 27, 2009·Cost Effectiveness and Resource Allocation : C/E·Trine S Bergmo
May 3, 2016·Advances in Wound Care·Rúben F Pereira, Paulo J Bártolo
May 10, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Joachim DissemondKarl-Christian Münter
May 10, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Joachim DissemondKarl-Christian Münter
May 4, 2011·Journal of Wound Care·C MillerL Karimi
Aug 10, 2012·British Journal of Community Nursing·Jane Menon
Jun 16, 2018·The Cochrane Database of Systematic Reviews·Gill NormanJo C Dumville
Jan 11, 2014·The Cochrane Database of Systematic Reviews·Susan O'MearaRachel Richardson
Sep 12, 2018·Journal of Wound Care·Ruth ScullyPhilip Bowler
Sep 29, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Tomoya SatoShigeru Ichioka
Feb 16, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Lisa Gould, William W Li
May 17, 2019·Biomaterials Science·Susheel Kumar NethiSudip Mukherjee
Sep 13, 2019·Journal of Wound Care·Emma J WoodmanseyPaul A Gunning
Sep 13, 2019·Journal of Wound Care·David Parsons, Philip Bowler
Jul 14, 2020·Journal of Wound Care·Randall D WolcottMichel He Hermans
Apr 17, 2019·Frontiers in Microbiology·Mansura S MulaniKarishma R Pardesi
Feb 28, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Ka-Kit TsangThomas Kwok-Shing Wong

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